TIMP1 protein (Ovis aries) - STRING interaction network

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TIMP1

Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (255 aa)

Predicted Functional Partners:

MMP9

0.998

MMP1

0.954

MMP14

0.944

MMP8

0.912

MMP3

0.903

MMP2

0.900

ELSPBP1

0.866

CD63

0.862

IL1B

0.838

W5P7F8_SHEEP

0.830

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD63	IL1B	ENSOARP00000012124	ENSOARP00000022427	Tetraspanin.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.469
CD63	MMP9	ENSOARP00000012124	ENSOARP00000008487	Tetraspanin.	Matrix metallopeptidase 9.	0.416
CD63	TIMP1	ENSOARP00000012124	ENSOARP00000014098	Tetraspanin.	Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).	0.862
ELSPBP1	MMP1	ENSOARP00000012357	ENSOARP00000005708	Epididymal sperm binding protein 1.	Matrix metallopeptidase 1.	0.420
ELSPBP1	MMP2	ENSOARP00000012357	ENSOARP00000019362	Epididymal sperm binding protein 1.	Uncharacterized protein.	0.420
ELSPBP1	MMP3	ENSOARP00000012357	ENSOARP00000005456	Epididymal sperm binding protein 1.	Matrix metallopeptidase 3.	0.420
ELSPBP1	MMP8	ENSOARP00000012357	ENSOARP00000005883	Epididymal sperm binding protein 1.	Matrix metallopeptidase 8.	0.420
ELSPBP1	TIMP1	ENSOARP00000012357	ENSOARP00000014098	Epididymal sperm binding protein 1.	Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).	0.866
IL1B	CD63	ENSOARP00000022427	ENSOARP00000012124	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Tetraspanin.	0.469
IL1B	MMP1	ENSOARP00000022427	ENSOARP00000005708	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Matrix metallopeptidase 1.	0.727
IL1B	MMP2	ENSOARP00000022427	ENSOARP00000019362	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Uncharacterized protein.	0.559
IL1B	MMP3	ENSOARP00000022427	ENSOARP00000005456	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Matrix metallopeptidase 3.	0.788
IL1B	MMP8	ENSOARP00000022427	ENSOARP00000005883	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Matrix metallopeptidase 8.	0.627
IL1B	MMP9	ENSOARP00000022427	ENSOARP00000008487	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Matrix metallopeptidase 9.	0.914
IL1B	TIMP1	ENSOARP00000022427	ENSOARP00000014098	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).	0.838
MMP1	ELSPBP1	ENSOARP00000005708	ENSOARP00000012357	Matrix metallopeptidase 1.	Epididymal sperm binding protein 1.	0.420
MMP1	IL1B	ENSOARP00000005708	ENSOARP00000022427	Matrix metallopeptidase 1.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.727
MMP1	MMP14	ENSOARP00000005708	ENSOARP00000020855	Matrix metallopeptidase 1.	ZnMc domain-containing protein.	0.515
MMP1	MMP2	ENSOARP00000005708	ENSOARP00000019362	Matrix metallopeptidase 1.	Uncharacterized protein.	0.965
MMP1	MMP3	ENSOARP00000005708	ENSOARP00000005456	Matrix metallopeptidase 1.	Matrix metallopeptidase 3.	0.976

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