STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARF4ADP-ribosylation factor 4; Belongs to the small GTPase superfamily. Arf family. (180 aa)    
Predicted Functional Partners:
GBF1
Golgi brefeldin A resistant guanine nucleotide exchange factor 1.
    
 0.939
COPB1
Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
   
 0.878
COPA
Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.
   
 0.846
KDELR3
ER lumen protein-retaining receptor.
   
 0.846
ITSN2
Intersectin 2.
    
 0.833
GALNT5
Polypeptide N-acetylgalactosaminyltransferase.
      
 0.769
KDELR2
ER lumen protein-retaining receptor.
   
 0.757
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1.
    
 0.748
ITSN1
Intersectin 1.
    
 0.742
ARFGAP1
ADP ribosylation factor GTPase activating protein 1.
   
 0.735
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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