STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZEB1Zinc finger E-box binding homeobox 1. (1099 aa)    
Predicted Functional Partners:
ZEB2
Zinc finger E-box binding homeobox 2.
     
0.911
TWIST1
Twist family bHLH transcription factor 1.
     
 0.794
W5Q3P0_SHEEP
Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
   
 
 0.778
VIM
Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
      
 0.753
CDH2
Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.
   
  
 0.748
SNAI1
Snail family transcriptional repressor 1.
      
0.746
SMAD2
Mothers against decapentaplegic homolog.
   
 
 0.721
HDAC1
Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
   
 
 0.721
CDH1
Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.
   
  
 0.717
TWIST2
Twist family bHLH transcription factor 2.
     
 0.704
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.