W5PZL9_SHEEP protein (Ovis aries) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

W5PZL9_SHEEP

Uncharacterized protein. (700 aa)

Predicted Functional Partners:

CD24

0.699

CD163

0.658

TYROBP

0.626

SYK

0.594

IL4

0.580

CD52

0.575

SIGLEC15

0.569

CCDC136

0.554

W5P0A5_SHEEP

0.535

W5PDQ0_SHEEP

0.535

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC136	W5PZL9_SHEEP	ENSOARP00000003459	ENSOARP00000015905	Coiled-coil domain containing 136.	Uncharacterized protein.	0.554
CD163	IL4	ENSOARP00000003050	ENSOARP00000015980	CD163 molecule.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.769
CD163	SYK	ENSOARP00000003050	ENSOARP00000008390	CD163 molecule.	Tyrosine-protein kinase.	0.483
CD163	W5PZL9_SHEEP	ENSOARP00000003050	ENSOARP00000015905	CD163 molecule.	Uncharacterized protein.	0.658
CD24	IL4	ENSOARP00000011879	ENSOARP00000015980	Uncharacterized protein.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.403
CD24	W5PZL9_SHEEP	ENSOARP00000011879	ENSOARP00000015905	Uncharacterized protein.	Uncharacterized protein.	0.699
CD52	TYROBP	ENSOARP00000005150	ENSOARP00000005542	Uncharacterized protein.	TYRO protein tyrosine kinase binding protein.	0.463
CD52	W5PZL9_SHEEP	ENSOARP00000005150	ENSOARP00000015905	Uncharacterized protein.	Uncharacterized protein.	0.575
IL4	CD163	ENSOARP00000015980	ENSOARP00000003050	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	CD163 molecule.	0.769
IL4	CD24	ENSOARP00000015980	ENSOARP00000011879	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Uncharacterized protein.	0.403
IL4	SYK	ENSOARP00000015980	ENSOARP00000008390	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Tyrosine-protein kinase.	0.539
IL4	W5PZL9_SHEEP	ENSOARP00000015980	ENSOARP00000015905	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Uncharacterized protein.	0.580
SIGLEC15	TYROBP	ENSOARP00000002584	ENSOARP00000005542	Sialic acid binding Ig like lectin 15.	TYRO protein tyrosine kinase binding protein.	0.818
SIGLEC15	W5PZL9_SHEEP	ENSOARP00000002584	ENSOARP00000015905	Sialic acid binding Ig like lectin 15.	Uncharacterized protein.	0.569
SYK	CD163	ENSOARP00000008390	ENSOARP00000003050	Tyrosine-protein kinase.	CD163 molecule.	0.483
SYK	IL4	ENSOARP00000008390	ENSOARP00000015980	Tyrosine-protein kinase.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.539
SYK	TYROBP	ENSOARP00000008390	ENSOARP00000005542	Tyrosine-protein kinase.	TYRO protein tyrosine kinase binding protein.	0.993
SYK	W5PZL9_SHEEP	ENSOARP00000008390	ENSOARP00000015905	Tyrosine-protein kinase.	Uncharacterized protein.	0.594
TYROBP	CD52	ENSOARP00000005542	ENSOARP00000005150	TYRO protein tyrosine kinase binding protein.	Uncharacterized protein.	0.463
TYROBP	SIGLEC15	ENSOARP00000005542	ENSOARP00000002584	TYRO protein tyrosine kinase binding protein.	Sialic acid binding Ig like lectin 15.	0.818