STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EREGEpiregulin. (169 aa)    
Predicted Functional Partners:
EGFR
Receptor protein-tyrosine kinase.
    
 0.998
ERBB4
Receptor protein-tyrosine kinase.
    
 0.996
ERBB3
Erb-b2 receptor tyrosine kinase 3.
    
 0.970
AREG
Amphiregulin.
   
 
 0.965
EPGN
Epithelial mitogen.
     
 0.937
HBEGF
Heparin binding EGF like growth factor.
     
 0.928
ERBB2
Receptor protein-tyrosine kinase.
    
 0.926
TGFA
Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
     
 0.884
BTC
Betacellulin.
     
0.778
NRG4
Neuregulin 4.
     
 0.720
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.