MS4A8 protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MS4A8

Membrane spanning 4-domains A8. (251 aa)

Predicted Functional Partners:

DUPD1

0.695

SLC6A19

0.616

SERPINA10

0.572

PTH2R

0.572

LARS2

0.538

W5PNF3_SHEEP

0.482

W5NWS2_SHEEP

0.481

ANXA6

0.481

LARS

0.481

PLXNB2

0.481

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA6	DUPD1	ENSOARP00000008787	ENSOARP00000009366	Annexin.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.481
ANXA6	MS4A8	ENSOARP00000008787	ENSOARP00000016469	Annexin.	Membrane spanning 4-domains A8.	0.481
DUPD1	ANXA6	ENSOARP00000009366	ENSOARP00000008787	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Annexin.	0.481
DUPD1	LARS	ENSOARP00000009366	ENSOARP00000017083	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.482
DUPD1	LARS2	ENSOARP00000009366	ENSOARP00000011376	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.543
DUPD1	MS4A8	ENSOARP00000009366	ENSOARP00000016469	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Membrane spanning 4-domains A8.	0.695
DUPD1	PLXNB2	ENSOARP00000009366	ENSOARP00000021272	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Plexin B2.	0.497
DUPD1	PTH2R	ENSOARP00000009366	ENSOARP00000020487	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Parathyroid hormone 2 receptor; Belongs to the G-protein coupled receptor 2 family.	0.569
DUPD1	SERPINA10	ENSOARP00000009366	ENSOARP00000015861	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Serpin family A member 10; Belongs to the serpin family.	0.572
DUPD1	SLC6A19	ENSOARP00000009366	ENSOARP00000017658	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.613
DUPD1	W5NWS2_SHEEP	ENSOARP00000009366	ENSOARP00000002619	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.482
LARS	DUPD1	ENSOARP00000017083	ENSOARP00000009366	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.482
LARS	LARS2	ENSOARP00000017083	ENSOARP00000011376	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.923
LARS	MS4A8	ENSOARP00000017083	ENSOARP00000016469	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Membrane spanning 4-domains A8.	0.481
LARS2	DUPD1	ENSOARP00000011376	ENSOARP00000009366	Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.543
LARS2	LARS	ENSOARP00000011376	ENSOARP00000017083	Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.923
LARS2	MS4A8	ENSOARP00000011376	ENSOARP00000016469	Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Membrane spanning 4-domains A8.	0.538
LARS2	SLC6A19	ENSOARP00000011376	ENSOARP00000017658	Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.412
MS4A8	ANXA6	ENSOARP00000016469	ENSOARP00000008787	Membrane spanning 4-domains A8.	Annexin.	0.481
MS4A8	DUPD1	ENSOARP00000016469	ENSOARP00000009366	Membrane spanning 4-domains A8.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.695