STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RPS6KA3Non-specific serine/threonine protein kinase. (712 aa)    
Predicted Functional Partners:
RPS6KA1
Ribosomal protein S6 kinase.
  
 
0.981
MAPK3
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
0.974
MAPK1
Mitogen-activated protein kinase.
   
0.974
TSC2
TSC complex subunit 2.
    
 0.945
RPS6KA6
Non-specific serine/threonine protein kinase.
  
  
 
0.931
HRAS
HRas proto-oncogene, GTPase.
   
 0.927
KRAS
KRAS proto-oncogene, GTPase.
   
 0.919
TSC1
TSC complex subunit 1.
    
 0.915
NRAS
NRAS proto-oncogene, GTPase.
   
 0.915
ATF4
BZIP domain-containing protein.
     
 0.914
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: medium (64%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.