node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATM | RAD18 | ENSOARP00000012764 | ENSOARP00000007988 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | RAD18 E3 ubiquitin protein ligase. | 0.513 |
ATM | W5Q3Q0_SHEEP | ENSOARP00000012764 | ENSOARP00000017339 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | C2H2-type domain-containing protein. | 0.429 |
EFCAB6 | W5Q3Q0_SHEEP | ENSOARP00000020638 | ENSOARP00000017339 | EF-hand calcium binding domain 6. | C2H2-type domain-containing protein. | 0.513 |
FIBCD1 | W5Q3Q0_SHEEP | ENSOARP00000007934 | ENSOARP00000017339 | Fibrinogen C domain containing 1. | C2H2-type domain-containing protein. | 0.479 |
RAD18 | ATM | ENSOARP00000007988 | ENSOARP00000012764 | RAD18 E3 ubiquitin protein ligase. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.513 |
RAD18 | W5Q3Q0_SHEEP | ENSOARP00000007988 | ENSOARP00000017339 | RAD18 E3 ubiquitin protein ligase. | C2H2-type domain-containing protein. | 0.481 |
UBR1 | UBR2 | ENSOARP00000022117 | ENSOARP00000003864 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.425 |
UBR1 | UBR4 | ENSOARP00000022117 | ENSOARP00000010969 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | Ubiquitin protein ligase E3 component n-recognin 4. | 0.837 |
UBR1 | UBR5 | ENSOARP00000022117 | ENSOARP00000018851 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | Ubiquitin protein ligase E3 component n-recognin 5. | 0.791 |
UBR1 | W5Q3Q0_SHEEP | ENSOARP00000022117 | ENSOARP00000017339 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | C2H2-type domain-containing protein. | 0.478 |
UBR2 | UBR1 | ENSOARP00000003864 | ENSOARP00000022117 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.425 |
UBR2 | UBR3 | ENSOARP00000003864 | ENSOARP00000002983 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.411 |
UBR2 | UBR4 | ENSOARP00000003864 | ENSOARP00000010969 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | Ubiquitin protein ligase E3 component n-recognin 4. | 0.835 |
UBR2 | UBR5 | ENSOARP00000003864 | ENSOARP00000018851 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | Ubiquitin protein ligase E3 component n-recognin 5. | 0.650 |
UBR2 | W5Q3Q0_SHEEP | ENSOARP00000003864 | ENSOARP00000017339 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | C2H2-type domain-containing protein. | 0.483 |
UBR3 | UBR2 | ENSOARP00000002983 | ENSOARP00000003864 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.411 |
UBR3 | UBR4 | ENSOARP00000002983 | ENSOARP00000010969 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | Ubiquitin protein ligase E3 component n-recognin 4. | 0.539 |
UBR3 | UBR5 | ENSOARP00000002983 | ENSOARP00000018851 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | Ubiquitin protein ligase E3 component n-recognin 5. | 0.568 |
UBR3 | W5Q3Q0_SHEEP | ENSOARP00000002983 | ENSOARP00000017339 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | C2H2-type domain-containing protein. | 0.524 |
UBR4 | UBR1 | ENSOARP00000010969 | ENSOARP00000022117 | Ubiquitin protein ligase E3 component n-recognin 4. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.837 |