node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANO1 | CFTR | ENSOARP00000019131 | ENSOARP00000019474 | Anoctamin. | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | 0.597 |
ANO1 | SLC26A6 | ENSOARP00000019131 | ENSOARP00000017762 | Anoctamin. | Solute carrier family 26 member 6. | 0.613 |
CFTR | ANO1 | ENSOARP00000019474 | ENSOARP00000019131 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Anoctamin. | 0.597 |
CFTR | CLCN2 | ENSOARP00000019474 | ENSOARP00000022123 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Chloride channel protein. | 0.468 |
CFTR | SLC26A6 | ENSOARP00000019474 | ENSOARP00000017762 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Solute carrier family 26 member 6. | 0.811 |
CFTR | SLC9A1 | ENSOARP00000019474 | ENSOARP00000004093 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.504 |
CFTR | SLC9A2 | ENSOARP00000019474 | ENSOARP00000013982 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.457 |
CFTR | SLC9A3R1 | ENSOARP00000019474 | ENSOARP00000013120 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. | 0.991 |
CLCN2 | CFTR | ENSOARP00000022123 | ENSOARP00000019474 | Chloride channel protein. | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | 0.468 |
CLCN2 | RBP2 | ENSOARP00000022123 | ENSOARP00000007529 | Chloride channel protein. | Retinol binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.530 |
CLCN2 | SLC26A6 | ENSOARP00000022123 | ENSOARP00000017762 | Chloride channel protein. | Solute carrier family 26 member 6. | 0.581 |
CLCN2 | SLC6A6 | ENSOARP00000022123 | ENSOARP00000000240 | Chloride channel protein. | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.487 |
KCNS2 | SLC26A6 | ENSOARP00000015720 | ENSOARP00000017762 | Potassium voltage-gated channel modifier subfamily S member 2; Belongs to the potassium channel family. | Solute carrier family 26 member 6. | 0.720 |
RBP2 | CLCN2 | ENSOARP00000007529 | ENSOARP00000022123 | Retinol binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Chloride channel protein. | 0.530 |
RBP2 | SLC26A6 | ENSOARP00000007529 | ENSOARP00000017762 | Retinol binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Solute carrier family 26 member 6. | 0.597 |
RBP2 | SLC6A6 | ENSOARP00000007529 | ENSOARP00000000240 | Retinol binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.538 |
SLC26A6 | ANO1 | ENSOARP00000017762 | ENSOARP00000019131 | Solute carrier family 26 member 6. | Anoctamin. | 0.613 |
SLC26A6 | CFTR | ENSOARP00000017762 | ENSOARP00000019474 | Solute carrier family 26 member 6. | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | 0.811 |
SLC26A6 | CLCN2 | ENSOARP00000017762 | ENSOARP00000022123 | Solute carrier family 26 member 6. | Chloride channel protein. | 0.581 |
SLC26A6 | KCNS2 | ENSOARP00000017762 | ENSOARP00000015720 | Solute carrier family 26 member 6. | Potassium voltage-gated channel modifier subfamily S member 2; Belongs to the potassium channel family. | 0.720 |