STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT85Keratin 85; Belongs to the intermediate filament family. (362 aa)    
Predicted Functional Partners:
KRTAP11-1
Keratin-associated protein KAP11-1.
   
  
 0.755
RFX8
RFX family member 8, lacking RFX DNA binding domain.
      
 0.688
KRT35
Keratin, type I cuticular Ha5.
  
0.674
CERT1
Ceramide transporter 1.
      
 0.654
KRT27
IF rod domain-containing protein; Belongs to the intermediate filament family.
  
0.637
KRT28
Keratin 28; Belongs to the intermediate filament family.
  
0.614
DCAF11
DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat LEC14B family.
    
 0.609
TUSC1
Uncharacterized protein.
      
 0.595
ZNF354A
Uncharacterized protein.
      
 0.573
KRTAP8-1
Keratin-associated protein 8-1; In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
   
  
 0.571
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.