STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM97Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. (188 aa)    
Predicted Functional Partners:
SIGMAR1
Sigma non-opioid intracellular receptor 1.
   
  
 0.796
ARRDC4
Arrestin domain containing 4.
      
 0.730
PGRMC1
Uncharacterized protein.
      
 0.718
ZDHHC19
Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.
      
 0.678
KLF10
Kruppel like factor 10.
    
 0.590
LGALS4
Galectin.
    
 0.585
PACC1
Proton activated chloride channel 1.
      
 0.536
PDE4DIP
Phosphodiesterase 4D interacting protein.
    
 
 0.527
DDRGK1
DDRGK domain containing 1.
      
 0.512
MT4
Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.
      
 0.505
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.