STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABCA3ATP binding cassette subfamily A member 3. (1603 aa)    
Predicted Functional Partners:
SFTPB
Surfactant protein B.
      
 0.944
SFTPC
Pulmonary surfactant-associated protein C.
      
 0.929
AQP5
Aquaporin-5; Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity); Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.835
LPCAT1
Lysophosphatidylcholine acyltransferase 1.
   
 
 0.826
PCYT1A
Phosphate cytidylyltransferase 1, choline, alpha.
      
 0.826
SFTPA1
Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.
      
 0.750
SCNN1A
Sodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.658
HOPX
Homeobox domain-containing protein.
   
  
 0.585
SFTPD
C-type lectin domain-containing protein.
      
 0.564
ABCB1
Uncharacterized protein.
   
 0.541
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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