STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN12Protein tyrosine phosphatase non-receptor type 12. (782 aa)    
Predicted Functional Partners:
SHC1
SHC adaptor protein 1.
   
 0.962
EGFR
Receptor protein-tyrosine kinase.
    
 0.883
PSTPIP1
Proline-serine-threonine phosphatase interacting protein 1.
   
 
 0.710
RSBN1L
Round spermatid basic protein 1 like.
 
    
 0.688
TP53BP2
Tumor protein p53 binding protein 2.
   
 
 0.686
CSK
Tyrosine-protein kinase.
   
 0.676
MATK
Megakaryocyte-associated tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.
   
 0.676
GRB2
Growth factor receptor bound protein 2.
   
 0.645
PPP4R2
Protein phosphatase 4 regulatory subunit 2.
      
 0.615
SHC3
SHC adaptor protein 3.
   
 0.614
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.