node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BFSP1 | CRYAA | ENSOARP00000018803 | ENSOARP00000011991 | Beaded filament structural protein 1; Belongs to the intermediate filament family. | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | 0.920 |
BFSP1 | CRYAB | ENSOARP00000018803 | ENSOARP00000016300 | Beaded filament structural protein 1; Belongs to the intermediate filament family. | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. | 0.698 |
BFSP1 | CRYBB3 | ENSOARP00000018803 | ENSOARP00000020389 | Beaded filament structural protein 1; Belongs to the intermediate filament family. | Beta B3 crystallin; Belongs to the beta/gamma-crystallin family. | 0.701 |
BFSP1 | LIM2 | ENSOARP00000018803 | ENSOARP00000015849 | Beaded filament structural protein 1; Belongs to the intermediate filament family. | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. | 0.555 |
CRYAA | BFSP1 | ENSOARP00000011991 | ENSOARP00000018803 | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | Beaded filament structural protein 1; Belongs to the intermediate filament family. | 0.920 |
CRYAA | CRYAB | ENSOARP00000011991 | ENSOARP00000016300 | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. | 0.823 |
CRYAA | CRYBB3 | ENSOARP00000011991 | ENSOARP00000020389 | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | Beta B3 crystallin; Belongs to the beta/gamma-crystallin family. | 0.937 |
CRYAA | LIM2 | ENSOARP00000011991 | ENSOARP00000015849 | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. | 0.570 |
CRYAB | BFSP1 | ENSOARP00000016300 | ENSOARP00000018803 | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. | Beaded filament structural protein 1; Belongs to the intermediate filament family. | 0.698 |
CRYAB | CRYAA | ENSOARP00000016300 | ENSOARP00000011991 | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | 0.823 |
CRYAB | CRYBB3 | ENSOARP00000016300 | ENSOARP00000020389 | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. | Beta B3 crystallin; Belongs to the beta/gamma-crystallin family. | 0.753 |
CRYAB | LIM2 | ENSOARP00000016300 | ENSOARP00000015849 | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. | 0.486 |
CRYAB | TSC1 | ENSOARP00000016300 | ENSOARP00000006072 | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. | TSC complex subunit 1. | 0.457 |
CRYBB3 | BFSP1 | ENSOARP00000020389 | ENSOARP00000018803 | Beta B3 crystallin; Belongs to the beta/gamma-crystallin family. | Beaded filament structural protein 1; Belongs to the intermediate filament family. | 0.701 |
CRYBB3 | CRYAA | ENSOARP00000020389 | ENSOARP00000011991 | Beta B3 crystallin; Belongs to the beta/gamma-crystallin family. | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | 0.937 |
CRYBB3 | CRYAB | ENSOARP00000020389 | ENSOARP00000016300 | Beta B3 crystallin; Belongs to the beta/gamma-crystallin family. | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. | 0.753 |
CRYBB3 | ITSN1 | ENSOARP00000020389 | ENSOARP00000013825 | Beta B3 crystallin; Belongs to the beta/gamma-crystallin family. | Intersectin 1. | 0.742 |
CRYBB3 | ITSN2 | ENSOARP00000020389 | ENSOARP00000019246 | Beta B3 crystallin; Belongs to the beta/gamma-crystallin family. | Intersectin 2. | 0.834 |
CRYBB3 | LIM2 | ENSOARP00000020389 | ENSOARP00000015849 | Beta B3 crystallin; Belongs to the beta/gamma-crystallin family. | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. | 0.768 |
CRYBB3 | MTOR | ENSOARP00000020389 | ENSOARP00000002935 | Beta B3 crystallin; Belongs to the beta/gamma-crystallin family. | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.791 |