W5QCT5_SHEEP protein (Ovis aries) - STRING interaction network

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Predicted Interactions

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Score

W5QCT5_SHEEP

C2H2-type domain-containing protein. (769 aa)

Predicted Functional Partners:

UBR5

0.589

UBR3

0.524

EFCAB6

0.513

UBR2

0.483

RAD18

0.481

W5P5S9_SHEEP

0.480

FIBCD1

0.479

UBR1

0.478

UBR4

0.476

ATM

0.429

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	RAD18	ENSOARP00000012764	ENSOARP00000007988	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	RAD18 E3 ubiquitin protein ligase.	0.513
ATM	W5QCT5_SHEEP	ENSOARP00000012764	ENSOARP00000020533	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	C2H2-type domain-containing protein.	0.429
EFCAB6	W5QCT5_SHEEP	ENSOARP00000020638	ENSOARP00000020533	EF-hand calcium binding domain 6.	C2H2-type domain-containing protein.	0.513
FIBCD1	W5QCT5_SHEEP	ENSOARP00000007934	ENSOARP00000020533	Fibrinogen C domain containing 1.	C2H2-type domain-containing protein.	0.479
RAD18	ATM	ENSOARP00000007988	ENSOARP00000012764	RAD18 E3 ubiquitin protein ligase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.513
RAD18	W5QCT5_SHEEP	ENSOARP00000007988	ENSOARP00000020533	RAD18 E3 ubiquitin protein ligase.	C2H2-type domain-containing protein.	0.481
UBR1	UBR2	ENSOARP00000022117	ENSOARP00000003864	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.425
UBR1	UBR4	ENSOARP00000022117	ENSOARP00000010969	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin protein ligase E3 component n-recognin 4.	0.837
UBR1	UBR5	ENSOARP00000022117	ENSOARP00000018851	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin protein ligase E3 component n-recognin 5.	0.791
UBR1	W5QCT5_SHEEP	ENSOARP00000022117	ENSOARP00000020533	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	C2H2-type domain-containing protein.	0.478
UBR2	UBR1	ENSOARP00000003864	ENSOARP00000022117	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.425
UBR2	UBR3	ENSOARP00000003864	ENSOARP00000002983	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.411
UBR2	UBR4	ENSOARP00000003864	ENSOARP00000010969	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin protein ligase E3 component n-recognin 4.	0.835
UBR2	UBR5	ENSOARP00000003864	ENSOARP00000018851	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin protein ligase E3 component n-recognin 5.	0.650
UBR2	W5QCT5_SHEEP	ENSOARP00000003864	ENSOARP00000020533	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	C2H2-type domain-containing protein.	0.483
UBR3	UBR2	ENSOARP00000002983	ENSOARP00000003864	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.411
UBR3	UBR4	ENSOARP00000002983	ENSOARP00000010969	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin protein ligase E3 component n-recognin 4.	0.539
UBR3	UBR5	ENSOARP00000002983	ENSOARP00000018851	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin protein ligase E3 component n-recognin 5.	0.568
UBR3	W5QCT5_SHEEP	ENSOARP00000002983	ENSOARP00000020533	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	C2H2-type domain-containing protein.	0.524
UBR4	UBR1	ENSOARP00000010969	ENSOARP00000022117	Ubiquitin protein ligase E3 component n-recognin 4.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.837