STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PNPLA3Patatin like phospholipase domain containing 3. (435 aa)    
Predicted Functional Partners:
LIPC
Lipase C, hepatic type.
     
 0.937
LIPG
Lipase G, endothelial type.
     
 0.929
DGAT2
Diacylglycerol O-acyltransferase 2.
     
 0.928
PNLIPRP3
Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.
     
 0.928
PNLIP
Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.
     
 0.925
PNLIPRP2
Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.
     
 0.925
PNPLA2
PNPLA domain-containing protein.
  
  
0.924
MGLL
Monoglyceride lipase.
     
 0.917
LPL
Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans; Belongs to the AB hydrolase superfamily. Lipase family.
     
 0.909
PLPP4
Phospholipid phosphatase 4.
   
 
 0.906
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.