W5QDT6_SHEEP protein (Ovis aries) - STRING interaction network

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Predicted Interactions

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Score

W5QDT6_SHEEP

DUF1968 domain-containing protein. (161 aa)

Predicted Functional Partners:

B2M

0.808

ITK

0.799

RPA2

0.796

HLA-DRA

0.795

CD3E

0.788

W5Q4S2_SHEEP

0.749

FGB

0.742

CD2

0.734

W5P8R9_SHEEP

0.722

TRAV16

0.679

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	CD3E	ENSOARP00000004039	ENSOARP00000009648	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	0.683
B2M	HLA-DRA	ENSOARP00000004039	ENSOARP00000017840	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family.	0.617
B2M	W5QDT6_SHEEP	ENSOARP00000004039	ENSOARP00000020884	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	DUF1968 domain-containing protein.	0.808
CD2	CD3E	ENSOARP00000021742	ENSOARP00000009648	CD2 molecule.	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	0.945
CD2	HLA-DRA	ENSOARP00000021742	ENSOARP00000017840	CD2 molecule.	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family.	0.492
CD2	ITK	ENSOARP00000021742	ENSOARP00000011989	CD2 molecule.	Tyrosine-protein kinase.	0.773
CD2	W5P8R9_SHEEP	ENSOARP00000021742	ENSOARP00000006826	CD2 molecule.	Ig-like domain-containing protein.	0.434
CD2	W5QDT6_SHEEP	ENSOARP00000021742	ENSOARP00000020884	CD2 molecule.	DUF1968 domain-containing protein.	0.734
CD3E	B2M	ENSOARP00000009648	ENSOARP00000004039	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	0.683
CD3E	CD2	ENSOARP00000009648	ENSOARP00000021742	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	CD2 molecule.	0.945
CD3E	HLA-DRA	ENSOARP00000009648	ENSOARP00000017840	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family.	0.688
CD3E	ITK	ENSOARP00000009648	ENSOARP00000011989	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Tyrosine-protein kinase.	0.933
CD3E	RPA2	ENSOARP00000009648	ENSOARP00000003452	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Replication protein A2.	0.618
CD3E	W5P8R9_SHEEP	ENSOARP00000009648	ENSOARP00000006826	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Ig-like domain-containing protein.	0.711
CD3E	W5Q4S2_SHEEP	ENSOARP00000009648	ENSOARP00000017712	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Ig-like domain-containing protein.	0.615
CD3E	W5QDT6_SHEEP	ENSOARP00000009648	ENSOARP00000020884	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	DUF1968 domain-containing protein.	0.788
FGB	HLA-DRA	ENSOARP00000000285	ENSOARP00000017840	Fibrinogen beta chain.	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family.	0.742
FGB	W5QDT6_SHEEP	ENSOARP00000000285	ENSOARP00000020884	Fibrinogen beta chain.	DUF1968 domain-containing protein.	0.742
HLA-DRA	B2M	ENSOARP00000017840	ENSOARP00000004039	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	0.617
HLA-DRA	CD2	ENSOARP00000017840	ENSOARP00000021742	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family.	CD2 molecule.	0.492