STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOX4TOX high mobility group box family member 4. (619 aa)    
Predicted Functional Partners:
SUPT16H
SPT16 homolog, facilitates chromatin remodeling subunit.
   
 0.888
CHD8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]
    
 0.842
OR10G3
Olfactory receptor family 10 subfamily G member 3.
      
 0.828
OR5AU1
Olfactory receptor.
      
 0.828
SALL2
Spalt like transcription factor 2.
    
 
 0.828
WDR82
WD repeat domain 82.
    
 0.805
STARD3NL
STARD3 N-terminal like.
      
 0.780
HECW1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1.
    
 
 0.772
EPDR1
Ependymin related 1.
      
 0.758
OR10G2
Olfactory receptor family 10 subfamily G member 2.
      
 0.756
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.