IRAK4 protein (Ovis aries) - STRING interaction network

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Score

IRAK4

Protein kinase domain-containing protein. (460 aa)

Predicted Functional Partners:

MYD88

0.999

IRAK2

0.999

IRAK1

0.999

TRAF6

0.999

IKBKG

0.997

TLR4

0.991

TAB2

0.978

TAB3

0.976

TAB1

0.972

IL1R1

0.968

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IKBKG	IRAK1	ENSOARP00000004340	ENSOARP00000006297	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Interleukin 1 receptor associated kinase 1.	0.987
IKBKG	IRAK2	ENSOARP00000004340	ENSOARP00000005327	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Interleukin 1 receptor associated kinase 2.	0.884
IKBKG	IRAK4	ENSOARP00000004340	ENSOARP00000021135	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Protein kinase domain-containing protein.	0.997
IKBKG	MYD88	ENSOARP00000004340	ENSOARP00000001070	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.976
IKBKG	TAB1	ENSOARP00000004340	ENSOARP00000017835	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	TGF-beta activated kinase 1 (MAP3K7) binding protein 1.	0.998
IKBKG	TAB2	ENSOARP00000004340	ENSOARP00000002737	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.998
IKBKG	TAB3	ENSOARP00000004340	ENSOARP00000019557	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.998
IKBKG	TLR4	ENSOARP00000004340	ENSOARP00000006210	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.972
IKBKG	TRAF6	ENSOARP00000004340	ENSOARP00000020492	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
IL1R1	IRAK1	ENSOARP00000014081	ENSOARP00000006297	Interleukin 1 receptor type 1.	Interleukin 1 receptor associated kinase 1.	0.972
IL1R1	IRAK2	ENSOARP00000014081	ENSOARP00000005327	Interleukin 1 receptor type 1.	Interleukin 1 receptor associated kinase 2.	0.634
IL1R1	IRAK4	ENSOARP00000014081	ENSOARP00000021135	Interleukin 1 receptor type 1.	Protein kinase domain-containing protein.	0.968
IL1R1	MYD88	ENSOARP00000014081	ENSOARP00000001070	Interleukin 1 receptor type 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.993
IL1R1	TLR4	ENSOARP00000014081	ENSOARP00000006210	Interleukin 1 receptor type 1.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.612
IL1R1	TRAF6	ENSOARP00000014081	ENSOARP00000020492	Interleukin 1 receptor type 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.978
IRAK1	IKBKG	ENSOARP00000006297	ENSOARP00000004340	Interleukin 1 receptor associated kinase 1.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.987
IRAK1	IL1R1	ENSOARP00000006297	ENSOARP00000014081	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor type 1.	0.972
IRAK1	IRAK2	ENSOARP00000006297	ENSOARP00000005327	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 2.	0.991
IRAK1	IRAK4	ENSOARP00000006297	ENSOARP00000021135	Interleukin 1 receptor associated kinase 1.	Protein kinase domain-containing protein.	0.999
IRAK1	MYD88	ENSOARP00000006297	ENSOARP00000001070	Interleukin 1 receptor associated kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.999