STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLEKPleckstrin. (350 aa)    
Predicted Functional Partners:
CDC42
Cell division cycle 42.
   
 
 0.849
OSBP
Oxysterol-binding protein; Belongs to the OSBP family.
   
  
 0.836
RICTOR
RPTOR independent companion of MTOR complex 2.
      
 0.749
SRC
Tyrosine-protein kinase.
   
  
 0.746
PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
   
  
 0.724
RABIF
RAB interacting factor.
      
 0.722
BTK
Tyrosine-protein kinase.
   
  
 0.718
FARP1
FERM, ARH/RhoGEF and pleckstrin domain protein 1.
      
 0.696
BIN1-2
Uncharacterized protein.
   
 
 0.684
CNN2
Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
     
 0.679
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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