STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRASKRAS proto-oncogene, GTPase. (189 aa)    
Predicted Functional Partners:
NF1
Neurofibromin 1.
   
 0.999
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 0.996
EGFR
Receptor protein-tyrosine kinase.
   
 0.994
SRC
Tyrosine-protein kinase.
   
 0.982
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
   
 0.981
ARAF
Uncharacterized protein.
   
 0.980
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
   
 0.980
RGL1
Ral guanine nucleotide dissociation stimulator like 1.
   
 0.978
ALK
Tyrosine-protein kinase receptor.
   
 0.978
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.977
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.