STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VPS8VPS8 subunit of CORVET complex. (1332 aa)    
Predicted Functional Partners:
VPS11
Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.
    
 0.995
VPS18
VPS18 core subunit of CORVET and HOPS complexes.
    
 0.995
VPS16
Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.
    
 0.991
VPS39
VPS39 subunit of HOPS complex.
   
 
 0.971
VPS33A
Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.
    
 0.970
TGFBRAP1
Transforming growth factor beta receptor associated protein 1.
   
 0.952
VPS33B
Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.
    
 
 0.937
RAB5C
Uncharacterized protein.
    
 
 0.735
CCZ1
Uncharacterized protein.
      
 0.721
VAC14
VAC14 component of PIKFYVE complex.
   
  
 0.712
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.