STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFT44894.1Regulator of protease activity HflC, stomatin/prohibitin superfamily. (553 aa)    
Predicted Functional Partners:
ftsH
Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.919
SFT44880.1
Regulator of protease activity HflC, stomatin/prohibitin superfamily.
      
0.811
SFT71644.1
Membrane associated serine protease, rhomboid family.
   
 0.503
SFT76228.1
Membrane associated serine protease, rhomboid family.
   
 0.503
SFT74873.1
Predicted Zn-dependent peptidase.
   
 0.499
SFT74863.1
Predicted Zn-dependent peptidase.
   
 0.499
arc
Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
   
 
 0.488
SFT53290.1
Hypothetical protein.
  
    0.477
SFT72057.1
Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family.
   
    0.407
Your Current Organism:
Actinopolyspora righensis
NCBI taxonomy Id: 995060
Other names: A. righensis, Actinopolyspora righensis Meklat et al. 2014 emend. Nouioui et al. 2018, Actinopolyspora sp. H23, CCUG 63368, DSM 45501, MTCC 11562, strain H23
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.