STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFY31902.1PFAM: Cache domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterPro IPR004010:IPR003594; KEGG: npu:Npun_F3779 histidine kinase; PFAM: ATPase-like, ATP-binding domain; Cache; SMART: ATPase-like, ATP-binding domain; SPTR: Putative Sensor protein. (642 aa)    
Predicted Functional Partners:
AFY35112.1
PFAM: Response regulator receiver domain; GAF domain; COGs: COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain; InterPro IPR001789:IPR003018; KEGG: npu:Npun_R4435 response regulator receiver modulated GAF sensor protein; PFAM: Signal transduction response regulator, receiver domain; GAF; SMART: Signal transduction response regulator, receiver domain; GAF; SPTR: Response regulator receiver modulated GAF sensor protein.
 
 
 0.791
AFY33228.1
Protein serine/threonine phosphatase with GAF(s) sensor(s); PFAM: Response regulator receiver domain; GAF domain; Stage II sporulation protein E (SpoIIE); COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001789:IPR003018:IPR001932:IPR010822; KEGG: npu:Npun_R5135 response regulator receiver modulated serine phosphatase with GAF sensor; PFAM: Sporulation stage II, protein E C-terminal; Signal transduction response regulator, receiver domain; GAF; SMART: Protein phosphatase 2C-like; Signal transduction response regulator, receiver domain; GAF; SPTR: Response r [...]
 
 
 
 0.725
AFY35147.1
Adenylate/guanylate cyclase with GAF sensor(s); PFAM: Adenylate and Guanylate cyclase catalytic domain; GAF domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterProIPR001789:IPR003018:IPR003661:IPR003594:IPR 001054:IPR019278; KEGG: npu:Npun_R0896 multi-sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction response regulator, receiver domain; GAF; Domain of unknown function DUF2308, sensory; Signal transducti [...]
 
 
0.623
AFY34690.1
PAS/PAC sensor hybrid histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR001610:IPR003661:IPR003594:IPR 001789:IPR013656:IPR013655; KEGG: npu:Npun_F2908 multi-sensor hybrid histidine kinase; PFAM: Signal transduction response regulator, receiver domain; ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS [...]
  
 
 0.540
AFY34285.1
PAS/PAC sensor hybrid histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR001789:IPR003661:IPR003594:IPR 013767; KEGG: npu:Npun_R2901 multi-sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; Signal transduction response regulator, receiver domain; PAS fold; SMART: ATPase [...]
 
 
0.538
AFY35273.1
Multi-component transcriptional regulator, winged helix family; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; Transcriptional regulatory protein, C terminal; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterProIPR001789:IPR001867:IPR000014:IPR003661:IPR 003594:IPR008207:IPR013767:IPR013955; KEGG: ana:alr2428 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-bind [...]
 
 
 
 0.533
AFY30750.1
GAF sensor hybrid histidine kinase; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterProIPR003660:IPR003018:IPR003661:IPR003594:IPR 001789; KEGG: npu:Npun_F2686 GAF sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; GAF; HAMP linker domain; Signal transduction response regulator, receiver domain; SMART: ATPase-like, ATP-bind [...]
  
 
0.493
AFY35328.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; GAF domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR001789:IPR013767:IPR003018:IPR013656:IPR 013655:IPR003661:IPR003594:IPR000014:IPR001610; KEGG: ana:all0729 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction response regulator, receiver domain; PAS fold; GAF; PAS fold-4; PAS fold-3; Signal transduction histidine kinase, subgroup 1, dimeris [...]
 
 
 0.438
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
       0.434
AFY30799.1
Multi-sensor signal transduction histidine kinase; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR001789:IPR000014:IPR001610:IPR003661:IPR 003594:IPR013655; KEGG: ana:all2897 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; PAS fold-3; Signal transduction response regulator, receiver domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoaccep [...]
 
 
 
 0.423
Your Current Organism:
Calothrix sp. PCC7507
NCBI taxonomy Id: 99598
Other names: C. sp. PCC 7507, Calothrix sp. PCC 7507
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