AFY33315.1 protein (Calothrix sp. PCC7507) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AFY33315.1

KEGG: npu:Npun_R5201 hypothetical protein; SPTR: Putative uncharacterized protein. (48 aa)

Predicted Functional Partners:

AFY36343.1

0.862

AFY33314.1

0.465

Your Current Organism:

Calothrix sp. PCC7507

NCBI taxonomy Id: 99598
Other names: C. sp. PCC 7507, Calothrix sp. PCC 7507

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFY33314.1	AFY33315.1	Cal7507_2899	Cal7507_2900	Helix-turn-helix domain protein; PFAM: Helix-turn-helix; InterPro IPR001387; KEGG: npu:Npun_R5200 XRE family transcriptional regulator; PFAM: Helix-turn-helix type 3; SMART: Helix-turn-helix type 3; SPTR: Transcriptional regulator, XRE family.	KEGG: npu:Npun_R5201 hypothetical protein; SPTR: Putative uncharacterized protein.	0.465
AFY33315.1	AFY33314.1	Cal7507_2900	Cal7507_2899	KEGG: npu:Npun_R5201 hypothetical protein; SPTR: Putative uncharacterized protein.	Helix-turn-helix domain protein; PFAM: Helix-turn-helix; InterPro IPR001387; KEGG: npu:Npun_R5200 XRE family transcriptional regulator; PFAM: Helix-turn-helix type 3; SMART: Helix-turn-helix type 3; SPTR: Transcriptional regulator, XRE family.	0.465
AFY33315.1	AFY36343.1	Cal7507_2900	Cal7507_6039	KEGG: npu:Npun_R5201 hypothetical protein; SPTR: Putative uncharacterized protein.	Cystathionine beta-synthase; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; cystathionine beta-synthase; COGs: COG0031 Cysteine synthase; InterPro IPR005857:IPR001926:IPR000644; KEGG: ava:Ava_4156 cystathionine beta-synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Cystathionine beta-synthase, core; PRIAM: Cysteine synthase; SMART: Cystathionine beta-synthase, core; SPTR: Cystathionine beta-synthase; TIGRFAM: Cystathionine beta-synthase.	0.862
AFY36343.1	AFY33315.1	Cal7507_6039	Cal7507_2900	Cystathionine beta-synthase; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; cystathionine beta-synthase; COGs: COG0031 Cysteine synthase; InterPro IPR005857:IPR001926:IPR000644; KEGG: ava:Ava_4156 cystathionine beta-synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Cystathionine beta-synthase, core; PRIAM: Cysteine synthase; SMART: Cystathionine beta-synthase, core; SPTR: Cystathionine beta-synthase; TIGRFAM: Cystathionine beta-synthase.	KEGG: npu:Npun_R5201 hypothetical protein; SPTR: Putative uncharacterized protein.	0.862

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.877

expected number of edges:

11

PPI enrichment p-value:

1.98e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000103

Sulfate assimilation

7 of 9

2.99

8.05

6.82e-16

GO:0006783

Heme biosynthetic process

6 of 13

2.76

6.1

2.23e-12

GO:0006782

Protoporphyrinogen IX biosynthetic process

4 of 7

2.86

4.13

2.24e-08

GO:0070814

Hydrogen sulfide biosynthetic process

3 of 4

2.97

3.02

3.01e-06

GO:0044272

Sulfur compound biosynthetic process

4 of 58

1.94

2.2

2.26e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004783

Sulfite reductase (NADPH) activity

2 of 2

3.1

1.42

0.0027

GO:0016667

Oxidoreductase activity, acting on a sulfur group of donors

3 of 38

2.0

1.32

0.0027

GO:0016829

Lyase activity

4 of 205

1.39

0.99

0.0048

GO:0003824

Catalytic activity

11 of 3985

0.54

0.43

0.0018

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009337

Sulfite reductase complex (NADPH)

2 of 2

3.1

1.42

0.0027

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11702

Mixed, incl. Sulfur amino acid metabolic process, and Molybdenum ion binding

11 of 109

2.1

7.26

2.31e-20

CL:11879

Heme biosynthetic process

6 of 11

2.84

6.57

3.42e-13

CL:11881

Heme biosynthetic process

5 of 5

3.1

5.98

9.61e-12

CL:11755

Sulfate assimilation

5 of 5

3.1

5.98

9.61e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00860

Porphyrin and chlorophyll metabolism

6 of 55

2.14

4.29

3.83e-10

map00920

Sulfur metabolism

5 of 46

2.13

3.64

1.86e-08

map01110

Biosynthesis of secondary metabolites

7 of 669

1.12

1.26

6.63e-06

map01100

Metabolic pathways

11 of 2462

0.75

0.76

2.91e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-189451

Heme biosynthesis

4 of 14

2.55

3.28

6.25e-07

MAP-189445

Metabolism of porphyrins

4 of 15

2.52

3.26

6.25e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0627

Porphyrin biosynthesis

2 of 4

2.8

1.47

0.0021

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002891

Adenylyl-sulfate kinase

2 of 2

3.1

1.1

0.0106

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Neighborhood

Experiments

Cooccurrence

Textmining

Coexpression

Databases

Fusion

© STRING Consortium 2024

Credits

Access

Info

About