STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
grpE-2Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (254 aa)    
Predicted Functional Partners:
AFY35346.1
PFAM: Hsp70 protein; COGs: COG0443 Molecular chaperone; InterPro IPR013126; KEGG: nhl:Nhal_2517 heat shock protein 70; PFAM: Heat shock protein 70; SPTR: Heat shock protein 70.
 
 
 0.828
groS
10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
 
 0.800
groL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.788
groL-2
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.788
hrcA
Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
  
  
 0.786
dnaK
Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.763
dnaK-2
Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.763
dnaK-3
Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.763
AFY32889.1
PFAM: Hsp70 protein; COGs: COG0443 Molecular chaperone; InterPro IPR013126; KEGG: npu:Npun_R2724 heat shock protein 70; PFAM: Heat shock protein 70; SPTR: Heat shock protein 70.
  
 
 0.738
AFY34293.1
Hypothetical protein; PFAM: Virulence factor SrfB; KEGG: ana:alr1147 hypothetical protein; SPTR: Alr1147 protein.
  
 
 0.738
Your Current Organism:
Calothrix sp. PCC7507
NCBI taxonomy Id: 99598
Other names: C. sp. PCC 7507, Calothrix sp. PCC 7507
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