node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFY32520.1 | AFY35710.1 | Cal7507_2077 | Cal7507_5375 | PFAM: Bacterial sugar transferase; TIGRFAM: exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; COGs: COG2148 Sugar transferase involved in lipopolysaccharide synthesis; InterPro IPR017475:IPR003362; KEGG: npu:Npun_F4852 sugar transferase; PFAM: Bacterial sugar transferase; SPTR: Sugar transferase; TIGRFAM: Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | 0.500 |
AFY32520.1 | glmS | Cal7507_2077 | Cal7507_5028 | PFAM: Bacterial sugar transferase; TIGRFAM: exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; COGs: COG2148 Sugar transferase involved in lipopolysaccharide synthesis; InterPro IPR017475:IPR003362; KEGG: npu:Npun_F4852 sugar transferase; PFAM: Bacterial sugar transferase; SPTR: Sugar transferase; TIGRFAM: Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. | Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.437 |
AFY33691.1 | AFY35710.1 | Cal7507_3286 | Cal7507_5375 | TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase; COGs: COG1820 N-acetylglucosamine-6-phosphate deacetylase; InterPro IPR006680:IPR003764; KEGG: ana:all0988 N-acetyl-glucosamine-6-phosphate deacetylase; PFAM: Amidohydrolase 1; PRIAM: N-acetylglucosamine-6-phosphate deacetylase; SPTR: N-acetyl-glucosamine-6-phosphate deacetylase; TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase. | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | 0.572 |
AFY33691.1 | glmS | Cal7507_3286 | Cal7507_5028 | TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase; COGs: COG1820 N-acetylglucosamine-6-phosphate deacetylase; InterPro IPR006680:IPR003764; KEGG: ana:all0988 N-acetyl-glucosamine-6-phosphate deacetylase; PFAM: Amidohydrolase 1; PRIAM: N-acetylglucosamine-6-phosphate deacetylase; SPTR: N-acetyl-glucosamine-6-phosphate deacetylase; TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase. | Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.938 |
AFY35642.1 | AFY35710.1 | Cal7507_5304 | Cal7507_5375 | PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterPro IPR001697:IPR015793:IPR015795:IPR008279; KEGG: npu:Npun_F4277 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; PEP-utilising enzyme, mobile domain; PRIAM: Pyruvate kinase., Pyruvate, water dikinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; Belongs to the pyruvate kinase family. | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | 0.473 |
AFY35642.1 | AFY35711.1 | Cal7507_5304 | Cal7507_5376 | PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterPro IPR001697:IPR015793:IPR015795:IPR008279; KEGG: npu:Npun_F4277 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; PEP-utilising enzyme, mobile domain; PRIAM: Pyruvate kinase., Pyruvate, water dikinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; Belongs to the pyruvate kinase family. | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.401 |
AFY35710.1 | AFY32520.1 | Cal7507_5375 | Cal7507_2077 | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | PFAM: Bacterial sugar transferase; TIGRFAM: exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; COGs: COG2148 Sugar transferase involved in lipopolysaccharide synthesis; InterPro IPR017475:IPR003362; KEGG: npu:Npun_F4852 sugar transferase; PFAM: Bacterial sugar transferase; SPTR: Sugar transferase; TIGRFAM: Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. | 0.500 |
AFY35710.1 | AFY33691.1 | Cal7507_5375 | Cal7507_3286 | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase; COGs: COG1820 N-acetylglucosamine-6-phosphate deacetylase; InterPro IPR006680:IPR003764; KEGG: ana:all0988 N-acetyl-glucosamine-6-phosphate deacetylase; PFAM: Amidohydrolase 1; PRIAM: N-acetylglucosamine-6-phosphate deacetylase; SPTR: N-acetyl-glucosamine-6-phosphate deacetylase; TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase. | 0.572 |
AFY35710.1 | AFY35642.1 | Cal7507_5375 | Cal7507_5304 | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterPro IPR001697:IPR015793:IPR015795:IPR008279; KEGG: npu:Npun_F4277 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; PEP-utilising enzyme, mobile domain; PRIAM: Pyruvate kinase., Pyruvate, water dikinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.473 |
AFY35710.1 | AFY35711.1 | Cal7507_5375 | Cal7507_5376 | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.700 |
AFY35710.1 | AFY35894.1 | Cal7507_5375 | Cal7507_5567 | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | PFAM: Biotin/lipoate A/B protein ligase family; COGs: COG0095 Lipoate-protein ligase A; InterPro IPR004143; KEGG: npu:Npun_F6359 biotin/lipoate A/B protein ligase; PFAM: Biotin/lipoate A/B protein ligase; SPTR: Biotin/lipoate A/B protein ligase. | 0.483 |
AFY35710.1 | dacA | Cal7507_5375 | Cal7507_2553 | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. | 0.651 |
AFY35710.1 | glmS | Cal7507_5375 | Cal7507_5028 | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.680 |
AFY35710.1 | glmU | Cal7507_5375 | Cal7507_4782 | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | Bifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.645 |
AFY35710.1 | murC | Cal7507_5375 | Cal7507_0035 | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.480 |
AFY35710.1 | murI | Cal7507_5375 | Cal7507_0888 | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.459 |
AFY35711.1 | AFY35642.1 | Cal7507_5376 | Cal7507_5304 | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterPro IPR001697:IPR015793:IPR015795:IPR008279; KEGG: npu:Npun_F4277 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; PEP-utilising enzyme, mobile domain; PRIAM: Pyruvate kinase., Pyruvate, water dikinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.401 |
AFY35711.1 | AFY35710.1 | Cal7507_5376 | Cal7507_5375 | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | 0.700 |
AFY35711.1 | murI | Cal7507_5376 | Cal7507_0888 | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.922 |
AFY35894.1 | AFY35710.1 | Cal7507_5567 | Cal7507_5375 | PFAM: Biotin/lipoate A/B protein ligase family; COGs: COG0095 Lipoate-protein ligase A; InterPro IPR004143; KEGG: npu:Npun_F6359 biotin/lipoate A/B protein ligase; PFAM: Biotin/lipoate A/B protein ligase; SPTR: Biotin/lipoate A/B protein ligase. | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: npu:Npun_R4468 phosphoglucomutase/phosphomannomutase alpha/beta/subunit; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domai [...] | 0.483 |