STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFY36415.1PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type; COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR004439:IPR001804; KEGG: ava:Ava_4831 isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: Isocitrate dehydrogenase [NADP]; TIGRFAM: Isocitrate dehydrogenase NADP-dependent, prokaryotic. (473 aa)    
Predicted Functional Partners:
AFY34462.1
Aconitase; PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; TIGRFAM: aconitate hydratase 2; COGs: COG1049 Aconitase B; InterPro IPR004406:IPR015929:IPR001030; KEGG: ava:Ava_0569 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; PFAM: Aconitase B, N-terminal, bacterial; Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; SPTR: Aconitate hydratase 2; TIGRFAM: Aconitase B, bacterial; Belongs to the aconitase/IPM isomerase family.
  
 
 0.981
AFY32813.1
PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; COGs: COG0372 Citrate synthase; InterPro IPR002020:IPR011278; KEGG: npu:Npun_R5627 citrate synthase; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase type I; Belongs to the citrate synthase family.
 
 
 0.974
AFY35357.1
PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006097:IPR006096; KEGG: npu:Npun_F3641 Glu/Leu/Phe/Val dehydrogenase, C terminal; PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain; PRIAM: Glutamate dehydrogenase (NAD(P)(+)); SMART: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; SPTR: Glu/Leu/Phe/Val dehydrogenase, C terminal; Belongs to t [...]
   
 0.958
mdh
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
 
 
 0.952
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
  
 0.928
AFY32999.1
PFAM: ATP-grasp domain; TIGRFAM: succinyl-CoA synthetase, beta subunit; COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR013650; KEGG: npu:Npun_F5183 ATP-grasp domain-containing protein; PFAM: ATP-grasp fold, succinyl-CoA synthetase-type; PRIAM: Succinate--CoA ligase (ADP-forming); SPTR: ATP-grasp domain protein.
 
  
 0.921
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 
0.860
AFY32538.1
Fumarate hydratase class II; PFAM: Fumarase C C-terminus; Lyase; TIGRFAM: aspartate ammonia-lyase; COGs: COG1027 Aspartate ammonia-lyase; HAMAP: Fumarate hydratase, class II; InterPro IPR005677:IPR022761:IPR018951; KEGG: npu:Npun_F2551 aspartate ammonia-lyase; PFAM: Lyase 1, N-terminal; Fumarase C, C-terminal; PRIAM: Aspartate ammonia-lyase; SPTR: Fumarate lyase.
     
 0.844
argH
PFAM: Lyase; TIGRFAM: argininosuccinate lyase; COGs: COG0165 Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; InterPro IPR022761:IPR009049; KEGG: npu:Npun_F5831 argininosuccinate lyase; PFAM: Lyase 1, N-terminal; PRIAM: Argininosuccinate lyase; SPTR: Argininosuccinate lyase; TIGRFAM: Argininosuccinate lyase.
     
 0.843
AFY35608.1
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
     
 0.833
Your Current Organism:
Calothrix sp. PCC7507
NCBI taxonomy Id: 99598
Other names: C. sp. PCC 7507, Calothrix sp. PCC 7507
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