node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGY80021.1 | folC | HMPREF9129_0876 | HMPREF9129_0874 | Hypothetical protein. | Folylpolyglutamate synthase; COG: COG0285; Belongs to the folylpolyglutamate synthase family. | 0.588 |
EGY80021.1 | folP | HMPREF9129_0876 | HMPREF9129_0254 | Hypothetical protein. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.634 |
EGY80021.1 | pabA | HMPREF9129_0876 | HMPREF9129_0875 | Hypothetical protein. | Para-aminobenzoate/anthranilate synthase glutamine amidotransferase; COG: COG0512. | 0.998 |
EGY80021.1 | pabB | HMPREF9129_0876 | HMPREF9129_0877 | Hypothetical protein. | Para-aminobenzoate synthase; COG: COG0147. | 0.969 |
EGY80021.1 | sulD | HMPREF9129_0876 | HMPREF9129_2141 | Hypothetical protein. | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.701 |
fabG | fhs | HMPREF9129_0655 | HMPREF9129_1419 | 3-oxoacyl-[acyl-carrier-protein] reductase; COG: COG1028. | Formate-tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | 0.457 |
fabG | folC | HMPREF9129_0655 | HMPREF9129_0874 | 3-oxoacyl-[acyl-carrier-protein] reductase; COG: COG1028. | Folylpolyglutamate synthase; COG: COG0285; Belongs to the folylpolyglutamate synthase family. | 0.594 |
fabG | sulD | HMPREF9129_0655 | HMPREF9129_2141 | 3-oxoacyl-[acyl-carrier-protein] reductase; COG: COG1028. | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.536 |
fabG2 | fhs | HMPREF9129_1192 | HMPREF9129_1419 | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Formate-tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | 0.457 |
fabG2 | folC | HMPREF9129_1192 | HMPREF9129_0874 | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Folylpolyglutamate synthase; COG: COG0285; Belongs to the folylpolyglutamate synthase family. | 0.571 |
fabG2 | sulD | HMPREF9129_1192 | HMPREF9129_2141 | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.536 |
fhs | fabG | HMPREF9129_1419 | HMPREF9129_0655 | Formate-tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | 3-oxoacyl-[acyl-carrier-protein] reductase; COG: COG1028. | 0.457 |
fhs | fabG2 | HMPREF9129_1419 | HMPREF9129_1192 | Formate-tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.457 |
fhs | folA | HMPREF9129_1419 | HMPREF9129_1063 | Formate-tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; COG: COG0262. | 0.850 |
fhs | folC | HMPREF9129_1419 | HMPREF9129_0874 | Formate-tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | Folylpolyglutamate synthase; COG: COG0285; Belongs to the folylpolyglutamate synthase family. | 0.661 |
fhs | sulD | HMPREF9129_1419 | HMPREF9129_2141 | Formate-tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.444 |
folA | fhs | HMPREF9129_1063 | HMPREF9129_1419 | Dihydrofolate reductase; COG: COG0262. | Formate-tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | 0.850 |
folA | folC | HMPREF9129_1063 | HMPREF9129_0874 | Dihydrofolate reductase; COG: COG0262. | Folylpolyglutamate synthase; COG: COG0285; Belongs to the folylpolyglutamate synthase family. | 0.928 |
folA | folP | HMPREF9129_1063 | HMPREF9129_0254 | Dihydrofolate reductase; COG: COG0262. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.536 |
folA | sulD | HMPREF9129_1063 | HMPREF9129_2141 | Dihydrofolate reductase; COG: COG0262. | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.408 |