| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EGQ15985.1 | guaA | HMPREF9144_1850 | HMPREF9144_0819 | 5'-nucleotidase precursor; COG: COG0737. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.833 |
| EGQ15985.1 | guaB | HMPREF9144_1850 | HMPREF9144_0696 | 5'-nucleotidase precursor; COG: COG0737. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.929 |
| EGQ15985.1 | hpt | HMPREF9144_1850 | HMPREF9144_1788 | 5'-nucleotidase precursor; COG: COG0737. | Hypoxanthine phosphoribosyltransferase; COG: COG0634; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.825 |
| EGQ15985.1 | purA | HMPREF9144_1850 | HMPREF9144_1386 | 5'-nucleotidase precursor; COG: COG0737. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.830 |
| EGQ15985.1 | purH2 | HMPREF9144_1850 | HMPREF9144_1730 | 5'-nucleotidase precursor; COG: COG0737. | Bifunctional purine biosynthesis protein PurH; COG: COG0138. | 0.825 |
| EGQ15985.1 | surE | HMPREF9144_1850 | HMPREF9144_0673 | 5'-nucleotidase precursor; COG: COG0737. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.836 |
| guaA | EGQ15985.1 | HMPREF9144_0819 | HMPREF9144_1850 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 5'-nucleotidase precursor; COG: COG0737. | 0.833 |
| guaA | guaB | HMPREF9144_0819 | HMPREF9144_0696 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | hpt | HMPREF9144_0819 | HMPREF9144_1788 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Hypoxanthine phosphoribosyltransferase; COG: COG0634; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.936 |
| guaA | purA | HMPREF9144_0819 | HMPREF9144_1386 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.911 |
| guaA | purH | HMPREF9144_0819 | HMPREF9144_0776 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Bifunctional purine biosynthesis protein PurH; COG: COG0138. | 0.867 |
| guaA | purH2 | HMPREF9144_0819 | HMPREF9144_1730 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Bifunctional purine biosynthesis protein PurH; COG: COG0138. | 0.849 |
| guaA | purL | HMPREF9144_0819 | HMPREF9144_0574 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.990 |
| guaA | rplC | HMPREF9144_0819 | HMPREF9144_1934 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.528 |
| guaA | rpsC | HMPREF9144_0819 | HMPREF9144_1928 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. | 0.839 |
| guaA | surE | HMPREF9144_0819 | HMPREF9144_0673 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.928 |
| guaB | EGQ15985.1 | HMPREF9144_0696 | HMPREF9144_1850 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 5'-nucleotidase precursor; COG: COG0737. | 0.929 |
| guaB | guaA | HMPREF9144_0696 | HMPREF9144_0819 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | hpt | HMPREF9144_0696 | HMPREF9144_1788 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypoxanthine phosphoribosyltransferase; COG: COG0634; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.914 |
| guaB | purA | HMPREF9144_0696 | HMPREF9144_1386 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.975 |
