Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPIRE1Spire type actin nucleation factor 1. (644 aa)    
Predicted Functional Partners:
ENSSDAP00000011382
annotation not available
    
 0.975
FMN2
Formin 2.
    
 0.975
GRAP2
GRB2 related adaptor protein 2.
   
 0.971
GRB2
Growth factor receptor bound protein 2.
    
 0.967
FYB1
FYN binding protein 1.
   
 0.889
ENSSDAP00000004274
annotation not available
   
 0.888
ENSSDAP00000020287
annotation not available
   
 0.888
NCK1
NCK adaptor protein 1.
    
 0.872
NCK2
NCK adaptor protein 2.
    
 0.872
VAV3
Vav guanine nucleotide exchange factor 3.
   
 0.859
Your Current Organism:
Spermophilus dauricus
NCBI taxonomy Id: 99837
Other names: Citellus dauricus, Daurian ground squirrel, S. dauricus
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