close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPIRE1Spire type actin nucleation factor 1. (644 aa)    
Predicted Functional Partners:
GRAP2
GRB2 related adaptor protein 2.
   
 0.971
ENSSDAP00000011382
annotation not available
    
 0.957
FMN2
Formin 2.
    
 0.957
GRB2
Growth factor receptor bound protein 2.
   
 0.946
FYB1
FYN binding protein 1.
   
 0.861
NCK1
NCK adaptor protein 1.
    
 0.855
NCK2
NCK adaptor protein 2.
    
 0.855
BLNK
B cell linker.
   
 0.854
SKAP1
Src kinase associated phosphoprotein 1.
    
 0.834
ENSSDAP00000004274
annotation not available
   
 0.826
Your Current Organism:
Spermophilus dauricus
NCBI taxonomy Id: 99837
Other names: Citellus dauricus, Daurian ground squirrel, S. dauricus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.