Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
NR0B1Nuclear receptor subfamily 0 group B member 1. (471 aa)    
Predicted Functional Partners:
NR5A1
Nuclear receptor subfamily 5 group A member 1.
    
 0.997
NR5A2
Uncharacterized protein.
    
0.938
ENSOCUP00000027514
Uncharacterized protein.
    
 0.914
NANOG
Homeobox domain-containing protein.
   
 
 0.884
ESRRB
Estrogen related receptor beta.
    
0.872
ESRRG
Estrogen related receptor gamma.
    
 0.817
POU5F1
POU domain protein.
    
 0.779
ENSOCUP00000038999
Uncharacterized protein.
   
 
 0.772
SALL4
Spalt like transcription factor 4.
    
 0.752
AR
Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
    
 0.737
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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