NKX2-5 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NKX2-5

NK2 homeobox 5. (326 aa)

Predicted Functional Partners:

GATA4

0.999

TBX5

0.999

MEF2C

0.965

TBX20

0.953

HAND2

0.942

NPPA

0.924

SRF

0.911

MEF2A

0.903

TNNT2

0.893

ISL1

0.886

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GATA4	HAND2	ENSOCUP00000001897	ENSOCUP00000013968	GATA binding protein 4.	BHLH domain-containing protein.	0.943
GATA4	ISL1	ENSOCUP00000001897	ENSOCUP00000020036	GATA binding protein 4.	ISL LIM homeobox 1.	0.782
GATA4	MEF2A	ENSOCUP00000001897	ENSOCUP00000018692	GATA binding protein 4.	Myocyte enhancer factor 2A.	0.412
GATA4	MEF2C	ENSOCUP00000001897	ENSOCUP00000047636	GATA binding protein 4.	Myocyte enhancer factor 2C.	0.935
GATA4	NKX2-5	ENSOCUP00000001897	ENSOCUP00000000038	GATA binding protein 4.	NK2 homeobox 5.	0.999
GATA4	NPPA	ENSOCUP00000001897	ENSOCUP00000006321	GATA binding protein 4.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.833
GATA4	SRF	ENSOCUP00000001897	ENSOCUP00000002515	GATA binding protein 4.	Serum response factor.	0.948
GATA4	TBX20	ENSOCUP00000001897	ENSOCUP00000030383	GATA binding protein 4.	T-box transcription factor 20.	0.916
GATA4	TBX5	ENSOCUP00000001897	ENSOCUP00000010944	GATA binding protein 4.	T-box transcription factor 5.	0.965
GATA4	TNNT2	ENSOCUP00000001897	ENSOCUP00000018870	GATA binding protein 4.	Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	0.823
HAND2	GATA4	ENSOCUP00000013968	ENSOCUP00000001897	BHLH domain-containing protein.	GATA binding protein 4.	0.943
HAND2	ISL1	ENSOCUP00000013968	ENSOCUP00000020036	BHLH domain-containing protein.	ISL LIM homeobox 1.	0.816
HAND2	MEF2A	ENSOCUP00000013968	ENSOCUP00000018692	BHLH domain-containing protein.	Myocyte enhancer factor 2A.	0.440
HAND2	MEF2C	ENSOCUP00000013968	ENSOCUP00000047636	BHLH domain-containing protein.	Myocyte enhancer factor 2C.	0.804
HAND2	NKX2-5	ENSOCUP00000013968	ENSOCUP00000000038	BHLH domain-containing protein.	NK2 homeobox 5.	0.942
HAND2	NPPA	ENSOCUP00000013968	ENSOCUP00000006321	BHLH domain-containing protein.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.639
HAND2	SRF	ENSOCUP00000013968	ENSOCUP00000002515	BHLH domain-containing protein.	Serum response factor.	0.457
HAND2	TBX20	ENSOCUP00000013968	ENSOCUP00000030383	BHLH domain-containing protein.	T-box transcription factor 20.	0.810
HAND2	TBX5	ENSOCUP00000013968	ENSOCUP00000010944	BHLH domain-containing protein.	T-box transcription factor 5.	0.889
HAND2	TNNT2	ENSOCUP00000013968	ENSOCUP00000018870	BHLH domain-containing protein.	Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	0.628