MS4A8 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUPD1	MS4A8	ENSOCUP00000015498	ENSOCUP00000000068	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Membrane spanning 4-domains A8.	0.488
FCER1G	MS4A8	ENSOCUP00000033471	ENSOCUP00000000068	Fc fragment of IgE receptor Ig.	Membrane spanning 4-domains A8.	0.520
LARS1	MS4A8	ENSOCUP00000029971	ENSOCUP00000000068	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Membrane spanning 4-domains A8.	0.466
MS4A6A	MS4A8	ENSOCUP00000007842	ENSOCUP00000000068	Uncharacterized protein.	Membrane spanning 4-domains A8.	0.493
MS4A6A	SORL1	ENSOCUP00000007842	ENSOCUP00000009783	Uncharacterized protein.	Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic r [...]	0.512
MS4A8	DUPD1	ENSOCUP00000000068	ENSOCUP00000015498	Membrane spanning 4-domains A8.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.488
MS4A8	FCER1G	ENSOCUP00000000068	ENSOCUP00000033471	Membrane spanning 4-domains A8.	Fc fragment of IgE receptor Ig.	0.520
MS4A8	LARS1	ENSOCUP00000000068	ENSOCUP00000029971	Membrane spanning 4-domains A8.	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.466
MS4A8	MS4A6A	ENSOCUP00000000068	ENSOCUP00000007842	Membrane spanning 4-domains A8.	Uncharacterized protein.	0.493
MS4A8	SORL1	ENSOCUP00000000068	ENSOCUP00000009783	Membrane spanning 4-domains A8.	Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic r [...]	0.592
MS4A8	TAAR5	ENSOCUP00000000068	ENSOCUP00000020274	Membrane spanning 4-domains A8.	Trace amine associated receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.470
SORL1	MS4A6A	ENSOCUP00000009783	ENSOCUP00000007842	Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic r [...]	Uncharacterized protein.	0.512
SORL1	MS4A8	ENSOCUP00000009783	ENSOCUP00000000068	Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic r [...]	Membrane spanning 4-domains A8.	0.592
TAAR5	MS4A8	ENSOCUP00000020274	ENSOCUP00000000068	Trace amine associated receptor 5; Belongs to the G-protein coupled receptor 1 family.	Membrane spanning 4-domains A8.	0.470