Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
PLEKHA2Pleckstrin homology domain containing A2. (425 aa)    
Predicted Functional Partners:
PTPN13
Tyrosine-protein phosphatase non-receptor type 13; Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
    
 0.943
MYSM1
Myb like, SWIRM and MPN domains 1.
    
 0.755
SNTA1
Alpha-1-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).
    
   0.752
PLEKHA8
Pleckstrin homology domain containing A8.
      
 0.721
SNTB2
Syntrophin beta 2.
    
   0.696
MPDZ
Multiple PDZ domain crumbs cell polarity complex component.
    
   0.614
UTRN
Utrophin.
    
 
 0.605
PLEKHA4
Pleckstrin homology domain containing A4.
   
 0.552
SNTB1
Syntrophin beta 1.
    
   0.544
DCUN1D1
DCN1-like protein.
      
 0.534
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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