Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
HTRA4HtrA serine peptidase 4. (578 aa)    
Predicted Functional Partners:
GCM1
Glial cells missing transcription factor 1.
    
 
 0.858
PINK1
PTEN induced kinase 1.
    
 0.839
G1SDV6_RABIT
Uncharacterized protein.
    
 0.745
XIAP
RING-type domain-containing protein.
    
 0.745
BIRC5
Uncharacterized protein.
    
 0.740
SCP2
Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis (By similarity); In the N-terminal section; belongs to the thiolase-like superfamily. Thiolase family.
    
 0.714
MAPT
Microtubule-associated protein.
    
 
 0.678
BIRC6
Baculoviral IAP repeat containing 6.
    
 0.674
ECI2
ACB domain-containing protein.
    
 0.662
ACAN
Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
   
 
 0.643
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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