KDM1A protein (Oryctolagus cuniculus) - STRING interaction network

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KDM1A

Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (848 aa)

Predicted Functional Partners:

RCOR1

0.998

PHF21A

0.996

ZMYM2

0.991

ZNF217

0.985

ZMYM3

0.985

HDAC2

0.984

HMG20A

0.975

ZNF516

0.974

RCOR3

0.962

RCOR2

0.962

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HDAC2	HMG20A	ENSOCUP00000040151	ENSOCUP00000004899	Histone deacetylase 2.	High mobility group 20A.	0.948
HDAC2	KDM1A	ENSOCUP00000040151	ENSOCUP00000001013	Histone deacetylase 2.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.984
HDAC2	PHF21A	ENSOCUP00000040151	ENSOCUP00000001434	Histone deacetylase 2.	PHD finger protein 21A.	0.933
HDAC2	RCOR1	ENSOCUP00000040151	ENSOCUP00000043168	Histone deacetylase 2.	REST corepressor 1.	0.994
HDAC2	RCOR2	ENSOCUP00000040151	ENSOCUP00000025542	Histone deacetylase 2.	REST corepressor 2.	0.857
HDAC2	RCOR3	ENSOCUP00000040151	ENSOCUP00000007879	Histone deacetylase 2.	REST corepressor 3.	0.918
HDAC2	ZMYM2	ENSOCUP00000040151	ENSOCUP00000014688	Histone deacetylase 2.	Zinc finger MYM-type containing 2.	0.887
HDAC2	ZMYM3	ENSOCUP00000040151	ENSOCUP00000020325	Histone deacetylase 2.	Zinc finger MYM-type containing 3.	0.860
HDAC2	ZNF217	ENSOCUP00000040151	ENSOCUP00000009778	Histone deacetylase 2.	Zinc finger protein 217.	0.852
HDAC2	ZNF516	ENSOCUP00000040151	ENSOCUP00000040615	Histone deacetylase 2.	Zinc finger protein 516.	0.650
HMG20A	HDAC2	ENSOCUP00000004899	ENSOCUP00000040151	High mobility group 20A.	Histone deacetylase 2.	0.948
HMG20A	KDM1A	ENSOCUP00000004899	ENSOCUP00000001013	High mobility group 20A.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.975
HMG20A	PHF21A	ENSOCUP00000004899	ENSOCUP00000001434	High mobility group 20A.	PHD finger protein 21A.	0.974
HMG20A	RCOR1	ENSOCUP00000004899	ENSOCUP00000043168	High mobility group 20A.	REST corepressor 1.	0.971
HMG20A	RCOR2	ENSOCUP00000004899	ENSOCUP00000025542	High mobility group 20A.	REST corepressor 2.	0.865
HMG20A	RCOR3	ENSOCUP00000004899	ENSOCUP00000007879	High mobility group 20A.	REST corepressor 3.	0.969
KDM1A	HDAC2	ENSOCUP00000001013	ENSOCUP00000040151	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Histone deacetylase 2.	0.984
KDM1A	HMG20A	ENSOCUP00000001013	ENSOCUP00000004899	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	High mobility group 20A.	0.975
KDM1A	PHF21A	ENSOCUP00000001013	ENSOCUP00000001434	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	PHD finger protein 21A.	0.996
KDM1A	RCOR1	ENSOCUP00000001013	ENSOCUP00000043168	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	REST corepressor 1.	0.998

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