IL10RB protein (Oryctolagus cuniculus) - STRING interaction network

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Score

IL10RB

Interleukin 10 receptor subunit beta. (384 aa)

Predicted Functional Partners:

IL10RA

0.974

IL22

0.973

IL10

0.966

IL22RA1

0.963

IFNAR2

0.954

IFNLR1

0.945

IL26

0.925

PPP1CC

0.920

TYK2

0.919

STAT1

0.912

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IFNAR2	IFNLR1	ENSOCUP00000015936	ENSOCUP00000026487	Uncharacterized protein.	Interferon lambda receptor 1.	0.923
IFNAR2	IL10RA	ENSOCUP00000015936	ENSOCUP00000027490	Uncharacterized protein.	Interleukin 10 receptor subunit alpha.	0.629
IFNAR2	IL10RB	ENSOCUP00000015936	ENSOCUP00000001025	Uncharacterized protein.	Interleukin 10 receptor subunit beta.	0.954
IFNAR2	IL22	ENSOCUP00000015936	ENSOCUP00000001423	Uncharacterized protein.	Interleukin 22.	0.728
IFNAR2	STAT1	ENSOCUP00000015936	ENSOCUP00000039721	Uncharacterized protein.	Signal transducer and activator of transcription.	0.988
IFNAR2	TYK2	ENSOCUP00000015936	ENSOCUP00000036146	Uncharacterized protein.	Non-specific protein-tyrosine kinase.	0.986
IFNLR1	IFNAR2	ENSOCUP00000026487	ENSOCUP00000015936	Interferon lambda receptor 1.	Uncharacterized protein.	0.923
IFNLR1	IL10	ENSOCUP00000026487	ENSOCUP00000019534	Interferon lambda receptor 1.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.468
IFNLR1	IL10RB	ENSOCUP00000026487	ENSOCUP00000001025	Interferon lambda receptor 1.	Interleukin 10 receptor subunit beta.	0.945
IFNLR1	IL22	ENSOCUP00000026487	ENSOCUP00000001423	Interferon lambda receptor 1.	Interleukin 22.	0.416
IFNLR1	IL22RA1	ENSOCUP00000026487	ENSOCUP00000005829	Interferon lambda receptor 1.	Interleukin 22 receptor subunit alpha 1.	0.690
IFNLR1	IL26	ENSOCUP00000026487	ENSOCUP00000000432	Interferon lambda receptor 1.	Interleukin 26.	0.421
IFNLR1	STAT1	ENSOCUP00000026487	ENSOCUP00000039721	Interferon lambda receptor 1.	Signal transducer and activator of transcription.	0.950
IFNLR1	TYK2	ENSOCUP00000026487	ENSOCUP00000036146	Interferon lambda receptor 1.	Non-specific protein-tyrosine kinase.	0.965
IL10	IFNLR1	ENSOCUP00000019534	ENSOCUP00000026487	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interferon lambda receptor 1.	0.468
IL10	IL10RA	ENSOCUP00000019534	ENSOCUP00000027490	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit alpha.	0.997
IL10	IL10RB	ENSOCUP00000019534	ENSOCUP00000001025	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit beta.	0.966
IL10	IL22	ENSOCUP00000019534	ENSOCUP00000001423	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22.	0.986
IL10	IL22RA1	ENSOCUP00000019534	ENSOCUP00000005829	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22 receptor subunit alpha 1.	0.926
IL10	IL26	ENSOCUP00000019534	ENSOCUP00000000432	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 26.	0.944