COL10A1 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

COL10A1

C1q domain-containing protein. (664 aa)

Predicted Functional Partners:

MMP13

0.884

COL18A1

0.876

ACAN

0.869

RUNX2

0.855

SOX9

0.853

IHH

0.838

ALPL

0.753

ADAMTS5

0.750

ADAMTS4

0.748

COL6A2

0.728

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	ADAMTS4	ENSOCUP00000024918	ENSOCUP00000011609	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 4.	0.963
ACAN	ADAMTS5	ENSOCUP00000024918	ENSOCUP00000002482	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 5.	0.950
ACAN	ALPL	ENSOCUP00000024918	ENSOCUP00000003846	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Alkaline phosphatase.	0.665
ACAN	COL10A1	ENSOCUP00000024918	ENSOCUP00000001034	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	C1q domain-containing protein.	0.869
ACAN	IHH	ENSOCUP00000024918	ENSOCUP00000025121	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.770
ACAN	MMP13	ENSOCUP00000024918	ENSOCUP00000002145	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.936
ACAN	RUNX2	ENSOCUP00000024918	ENSOCUP00000010093	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	RUNX family transcription factor 2.	0.851
ACAN	SOX9	ENSOCUP00000024918	ENSOCUP00000010009	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	SRY-box transcription factor 9.	0.921
ADAMTS4	ACAN	ENSOCUP00000011609	ENSOCUP00000024918	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.963
ADAMTS4	COL10A1	ENSOCUP00000011609	ENSOCUP00000001034	ADAM metallopeptidase with thrombospondin type 1 motif 4.	C1q domain-containing protein.	0.748
ADAMTS4	IHH	ENSOCUP00000011609	ENSOCUP00000025121	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.479
ADAMTS4	MMP13	ENSOCUP00000011609	ENSOCUP00000002145	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.901
ADAMTS4	RUNX2	ENSOCUP00000011609	ENSOCUP00000010093	ADAM metallopeptidase with thrombospondin type 1 motif 4.	RUNX family transcription factor 2.	0.570
ADAMTS4	SOX9	ENSOCUP00000011609	ENSOCUP00000010009	ADAM metallopeptidase with thrombospondin type 1 motif 4.	SRY-box transcription factor 9.	0.698
ADAMTS5	ACAN	ENSOCUP00000002482	ENSOCUP00000024918	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.950
ADAMTS5	COL10A1	ENSOCUP00000002482	ENSOCUP00000001034	ADAM metallopeptidase with thrombospondin type 1 motif 5.	C1q domain-containing protein.	0.750
ADAMTS5	IHH	ENSOCUP00000002482	ENSOCUP00000025121	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.626
ADAMTS5	MMP13	ENSOCUP00000002482	ENSOCUP00000002145	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.921
ADAMTS5	RUNX2	ENSOCUP00000002482	ENSOCUP00000010093	ADAM metallopeptidase with thrombospondin type 1 motif 5.	RUNX family transcription factor 2.	0.699
ADAMTS5	SOX9	ENSOCUP00000002482	ENSOCUP00000010009	ADAM metallopeptidase with thrombospondin type 1 motif 5.	SRY-box transcription factor 9.	0.768