COL10A1 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

COL10A1

C1q domain-containing protein. (664 aa)

Predicted Functional Partners:

MMP13

0.887

COL18A1

0.885

ACAN

0.865

RUNX2

0.841

SOX9

0.833

IHH

0.797

COL6A2

0.766

ADAMTS5

0.749

PTHLH

0.703

SOX6

0.701

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	ADAMTS5	ENSOCUP00000024918	ENSOCUP00000002482	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 5.	0.978
ACAN	COL10A1	ENSOCUP00000024918	ENSOCUP00000001034	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	C1q domain-containing protein.	0.865
ACAN	IHH	ENSOCUP00000024918	ENSOCUP00000025121	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.761
ACAN	MMP13	ENSOCUP00000024918	ENSOCUP00000002145	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.950
ACAN	PTHLH	ENSOCUP00000024918	ENSOCUP00000027904	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity o [...]	0.647
ACAN	RUNX2	ENSOCUP00000024918	ENSOCUP00000010093	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	RUNX family transcription factor 2.	0.832
ACAN	SOX6	ENSOCUP00000024918	ENSOCUP00000031731	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	SRY-box transcription factor 6.	0.806
ACAN	SOX9	ENSOCUP00000024918	ENSOCUP00000010009	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	SRY-box transcription factor 9.	0.913
ADAMTS5	ACAN	ENSOCUP00000002482	ENSOCUP00000024918	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.978
ADAMTS5	COL10A1	ENSOCUP00000002482	ENSOCUP00000001034	ADAM metallopeptidase with thrombospondin type 1 motif 5.	C1q domain-containing protein.	0.749
ADAMTS5	IHH	ENSOCUP00000002482	ENSOCUP00000025121	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.627
ADAMTS5	MMP13	ENSOCUP00000002482	ENSOCUP00000002145	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.936
ADAMTS5	PTHLH	ENSOCUP00000002482	ENSOCUP00000027904	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity o [...]	0.472
ADAMTS5	RUNX2	ENSOCUP00000002482	ENSOCUP00000010093	ADAM metallopeptidase with thrombospondin type 1 motif 5.	RUNX family transcription factor 2.	0.688
ADAMTS5	SOX6	ENSOCUP00000002482	ENSOCUP00000031731	ADAM metallopeptidase with thrombospondin type 1 motif 5.	SRY-box transcription factor 6.	0.425
ADAMTS5	SOX9	ENSOCUP00000002482	ENSOCUP00000010009	ADAM metallopeptidase with thrombospondin type 1 motif 5.	SRY-box transcription factor 9.	0.759
COL10A1	ACAN	ENSOCUP00000001034	ENSOCUP00000024918	C1q domain-containing protein.	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.865
COL10A1	ADAMTS5	ENSOCUP00000001034	ENSOCUP00000002482	C1q domain-containing protein.	ADAM metallopeptidase with thrombospondin type 1 motif 5.	0.749
COL10A1	COL18A1	ENSOCUP00000001034	ENSOCUP00000021058	C1q domain-containing protein.	Endostatin domain-containing protein.	0.885
COL10A1	COL6A2	ENSOCUP00000001034	ENSOCUP00000000359	C1q domain-containing protein.	Uncharacterized protein.	0.766