EDN2 protein (Oryctolagus cuniculus) - STRING interaction network

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EDN2

Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. (360 aa)

Predicted Functional Partners:

EDNRB

0.971

EDNRA

0.969

EDN3

0.899

EDN1

0.896

GPR150

0.887

SSTR2

0.859

HTR1D

0.858

DRD2

0.858

ADRB2

0.858

HTR1F

0.858

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRB2	EDN1	ENSOCUP00000013826	ENSOCUP00000011526	Adrenoceptor beta 2.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.871
ADRB2	EDN2	ENSOCUP00000013826	ENSOCUP00000001041	Adrenoceptor beta 2.	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.858
ADRB2	EDN3	ENSOCUP00000013826	ENSOCUP00000046269	Adrenoceptor beta 2.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.863
ADRB2	HTR1D	ENSOCUP00000013826	ENSOCUP00000009551	Adrenoceptor beta 2.	5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...]	0.685
ADRB2	HTR1F	ENSOCUP00000013826	ENSOCUP00000018984	Adrenoceptor beta 2.	5-hydroxytryptamine receptor 1F.	0.478
DRD2	EDN1	ENSOCUP00000010023	ENSOCUP00000011526	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.873
DRD2	EDN2	ENSOCUP00000010023	ENSOCUP00000001041	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.858
DRD2	EDN3	ENSOCUP00000010023	ENSOCUP00000046269	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.863
DRD2	GPR150	ENSOCUP00000010023	ENSOCUP00000009361	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	G protein-coupled receptor 150.	0.422
EDN1	ADRB2	ENSOCUP00000011526	ENSOCUP00000013826	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Adrenoceptor beta 2.	0.871
EDN1	DRD2	ENSOCUP00000011526	ENSOCUP00000010023	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.873
EDN1	EDN2	ENSOCUP00000011526	ENSOCUP00000001041	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.896
EDN1	EDN3	ENSOCUP00000011526	ENSOCUP00000046269	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.885
EDN1	EDNRA	ENSOCUP00000011526	ENSOCUP00000001082	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.998
EDN1	EDNRB	ENSOCUP00000011526	ENSOCUP00000015272	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.	0.999
EDN1	GPR150	ENSOCUP00000011526	ENSOCUP00000009361	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	G protein-coupled receptor 150.	0.903
EDN1	HTR1D	ENSOCUP00000011526	ENSOCUP00000009551	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...]	0.865
EDN1	HTR1F	ENSOCUP00000011526	ENSOCUP00000018984	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	5-hydroxytryptamine receptor 1F.	0.865
EDN1	SSTR2	ENSOCUP00000011526	ENSOCUP00000008063	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.873
EDN2	ADRB2	ENSOCUP00000001041	ENSOCUP00000013826	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	Adrenoceptor beta 2.	0.858

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