SOCS2 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

SOCS2

Suppressor of cytokine signaling 2. (307 aa)

Predicted Functional Partners:

CUL5

0.983

STAT3

0.982

JAK2

0.976

STAT1

0.969

STAT5A

0.966

STAT5B

0.964

JAK1

0.958

IRS1

0.957

SOCS4

0.954

ELOB

0.929

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL5	ELOB	ENSOCUP00000009389	ENSOCUP00000008716	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Elongin B.	0.999
CUL5	JAK1	ENSOCUP00000009389	ENSOCUP00000005398	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Tyrosine-protein kinase.	0.497
CUL5	JAK2	ENSOCUP00000009389	ENSOCUP00000014491	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Tyrosine-protein kinase.	0.585
CUL5	SOCS2	ENSOCUP00000009389	ENSOCUP00000001084	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Suppressor of cytokine signaling 2.	0.983
CUL5	SOCS4	ENSOCUP00000009389	ENSOCUP00000003465	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Suppressor of cytokine signaling 4.	0.943
ELOB	CUL5	ENSOCUP00000008716	ENSOCUP00000009389	Elongin B.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.999
ELOB	JAK1	ENSOCUP00000008716	ENSOCUP00000005398	Elongin B.	Tyrosine-protein kinase.	0.520
ELOB	JAK2	ENSOCUP00000008716	ENSOCUP00000014491	Elongin B.	Tyrosine-protein kinase.	0.562
ELOB	SOCS2	ENSOCUP00000008716	ENSOCUP00000001084	Elongin B.	Suppressor of cytokine signaling 2.	0.929
ELOB	SOCS4	ENSOCUP00000008716	ENSOCUP00000003465	Elongin B.	Suppressor of cytokine signaling 4.	0.963
IRS1	JAK1	ENSOCUP00000006209	ENSOCUP00000005398	Insulin receptor substrate 1.	Tyrosine-protein kinase.	0.604
IRS1	JAK2	ENSOCUP00000006209	ENSOCUP00000014491	Insulin receptor substrate 1.	Tyrosine-protein kinase.	0.978
IRS1	SOCS2	ENSOCUP00000006209	ENSOCUP00000001084	Insulin receptor substrate 1.	Suppressor of cytokine signaling 2.	0.957
IRS1	SOCS4	ENSOCUP00000006209	ENSOCUP00000003465	Insulin receptor substrate 1.	Suppressor of cytokine signaling 4.	0.919
IRS1	STAT3	ENSOCUP00000006209	ENSOCUP00000009494	Insulin receptor substrate 1.	Signal transducer and activator of transcription.	0.632
JAK1	CUL5	ENSOCUP00000005398	ENSOCUP00000009389	Tyrosine-protein kinase.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.497
JAK1	ELOB	ENSOCUP00000005398	ENSOCUP00000008716	Tyrosine-protein kinase.	Elongin B.	0.520
JAK1	IRS1	ENSOCUP00000005398	ENSOCUP00000006209	Tyrosine-protein kinase.	Insulin receptor substrate 1.	0.604
JAK1	JAK2	ENSOCUP00000005398	ENSOCUP00000014491	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.994
JAK1	SOCS2	ENSOCUP00000005398	ENSOCUP00000001084	Tyrosine-protein kinase.	Suppressor of cytokine signaling 2.	0.958