DCK protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

DCK

Deoxycytidine kinase. (217 aa)

Predicted Functional Partners:

CDA

0.979

DCTD

0.952

NT5C2

0.949

CMPK1

0.946

NT5C

0.938

DGUOK

0.930

ADA

0.929

NT5C1A

0.924

PNP

0.921

TK1

0.902

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	CDA	ENSOCUP00000008708	ENSOCUP00000013963	Adenosine deaminase.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.608
ADA	DCK	ENSOCUP00000008708	ENSOCUP00000001093	Adenosine deaminase.	Deoxycytidine kinase.	0.929
ADA	DGUOK	ENSOCUP00000008708	ENSOCUP00000003179	Adenosine deaminase.	Deoxyguanosine kinase.	0.655
ADA	NT5C	ENSOCUP00000008708	ENSOCUP00000022117	Adenosine deaminase.	5', 3'-nucleotidase, cytosolic.	0.893
ADA	NT5C1A	ENSOCUP00000008708	ENSOCUP00000003713	Adenosine deaminase.	5'-nucleotidase, cytosolic IA.	0.870
ADA	NT5C2	ENSOCUP00000008708	ENSOCUP00000049621	Adenosine deaminase.	Uncharacterized protein.	0.899
ADA	PNP	ENSOCUP00000008708	ENSOCUP00000004354	Adenosine deaminase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.981
CDA	ADA	ENSOCUP00000013963	ENSOCUP00000008708	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Adenosine deaminase.	0.608
CDA	CMPK1	ENSOCUP00000013963	ENSOCUP00000010693	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.558
CDA	DCK	ENSOCUP00000013963	ENSOCUP00000001093	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Deoxycytidine kinase.	0.979
CDA	DCTD	ENSOCUP00000013963	ENSOCUP00000004065	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	dCMP deaminase.	0.703
CDA	DGUOK	ENSOCUP00000013963	ENSOCUP00000003179	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Deoxyguanosine kinase.	0.736
CDA	NT5C	ENSOCUP00000013963	ENSOCUP00000022117	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	5', 3'-nucleotidase, cytosolic.	0.901
CDA	NT5C1A	ENSOCUP00000013963	ENSOCUP00000003713	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	5'-nucleotidase, cytosolic IA.	0.880
CDA	NT5C2	ENSOCUP00000013963	ENSOCUP00000049621	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uncharacterized protein.	0.906
CDA	TK1	ENSOCUP00000013963	ENSOCUP00000046611	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Thymidine kinase.	0.924
CMPK1	CDA	ENSOCUP00000010693	ENSOCUP00000013963	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.558
CMPK1	DCK	ENSOCUP00000010693	ENSOCUP00000001093	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Deoxycytidine kinase.	0.946
CMPK1	DCTD	ENSOCUP00000010693	ENSOCUP00000004065	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	dCMP deaminase.	0.925
CMPK1	DGUOK	ENSOCUP00000010693	ENSOCUP00000003179	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Deoxyguanosine kinase.	0.771