node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC37L1 | FKBP5 | ENSOCUP00000003006 | ENSOCUP00000046356 | Cell division cycle 37 like 1. | Peptidylprolyl isomerase. | 0.462 |
CDC37L1 | HSP90AA1 | ENSOCUP00000003006 | ENSOCUP00000036544 | Cell division cycle 37 like 1. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.854 |
CDC37L1 | HSPA4 | ENSOCUP00000003006 | ENSOCUP00000007228 | Cell division cycle 37 like 1. | Heat shock protein family A (Hsp70) member 4. | 0.575 |
CDC37L1 | PPP5C | ENSOCUP00000003006 | ENSOCUP00000018147 | Cell division cycle 37 like 1. | Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Pa [...] | 0.920 |
CDC37L1 | PTGES3 | ENSOCUP00000003006 | ENSOCUP00000029851 | Cell division cycle 37 like 1. | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.709 |
CDC37L1 | STIP1 | ENSOCUP00000003006 | ENSOCUP00000029749 | Cell division cycle 37 like 1. | Stress induced phosphoprotein 1. | 0.917 |
FKBP5 | CDC37L1 | ENSOCUP00000046356 | ENSOCUP00000003006 | Peptidylprolyl isomerase. | Cell division cycle 37 like 1. | 0.462 |
FKBP5 | HSP90AA1 | ENSOCUP00000046356 | ENSOCUP00000036544 | Peptidylprolyl isomerase. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.845 |
FKBP5 | HSPA4 | ENSOCUP00000046356 | ENSOCUP00000007228 | Peptidylprolyl isomerase. | Heat shock protein family A (Hsp70) member 4. | 0.785 |
FKBP5 | HSPA5 | ENSOCUP00000046356 | ENSOCUP00000029180 | Peptidylprolyl isomerase. | Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. | 0.410 |
FKBP5 | HSPA8 | ENSOCUP00000046356 | ENSOCUP00000029474 | Peptidylprolyl isomerase. | Uncharacterized protein. | 0.472 |
FKBP5 | NR3C1 | ENSOCUP00000046356 | ENSOCUP00000046838 | Peptidylprolyl isomerase. | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.966 |
FKBP5 | PPP5C | ENSOCUP00000046356 | ENSOCUP00000018147 | Peptidylprolyl isomerase. | Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Pa [...] | 0.588 |
FKBP5 | PTGES3 | ENSOCUP00000046356 | ENSOCUP00000029851 | Peptidylprolyl isomerase. | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.957 |
FKBP5 | STIP1 | ENSOCUP00000046356 | ENSOCUP00000029749 | Peptidylprolyl isomerase. | Stress induced phosphoprotein 1. | 0.810 |
HSP90AA1 | CDC37L1 | ENSOCUP00000036544 | ENSOCUP00000003006 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Cell division cycle 37 like 1. | 0.854 |
HSP90AA1 | FKBP5 | ENSOCUP00000036544 | ENSOCUP00000046356 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Peptidylprolyl isomerase. | 0.845 |
HSP90AA1 | HSPA4 | ENSOCUP00000036544 | ENSOCUP00000007228 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Heat shock protein family A (Hsp70) member 4. | 0.865 |
HSP90AA1 | HSPA5 | ENSOCUP00000036544 | ENSOCUP00000029180 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. | 0.856 |
HSP90AA1 | HSPA8 | ENSOCUP00000036544 | ENSOCUP00000029474 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Uncharacterized protein. | 0.941 |