| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGXT | CBS | ENSOCUP00000022506 | ENSOCUP00000034549 | Serine--pyruvate aminotransferase. | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | 0.951 |
| AGXT | SHMT1 | ENSOCUP00000022506 | ENSOCUP00000017814 | Serine--pyruvate aminotransferase. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.991 |
| AGXT | SPTLC1 | ENSOCUP00000022506 | ENSOCUP00000030336 | Serine--pyruvate aminotransferase. | Serine palmitoyltransferase long chain base subunit 1. | 0.858 |
| AGXT | SPTLC2 | ENSOCUP00000022506 | ENSOCUP00000040528 | Serine--pyruvate aminotransferase. | Serine palmitoyltransferase long chain base subunit 2. | 0.858 |
| AGXT | SPTLC3 | ENSOCUP00000022506 | ENSOCUP00000001125 | Serine--pyruvate aminotransferase. | Serine palmitoyltransferase long chain base subunit 3. | 0.859 |
| CBS | AGXT | ENSOCUP00000034549 | ENSOCUP00000022506 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Serine--pyruvate aminotransferase. | 0.951 |
| CBS | SHMT1 | ENSOCUP00000034549 | ENSOCUP00000017814 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.973 |
| CBS | SPTLC1 | ENSOCUP00000034549 | ENSOCUP00000030336 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Serine palmitoyltransferase long chain base subunit 1. | 0.852 |
| CBS | SPTLC2 | ENSOCUP00000034549 | ENSOCUP00000040528 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Serine palmitoyltransferase long chain base subunit 2. | 0.852 |
| CBS | SPTLC3 | ENSOCUP00000034549 | ENSOCUP00000001125 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Serine palmitoyltransferase long chain base subunit 3. | 0.853 |
| KDSR | ORMDL1 | ENSOCUP00000012169 | ENSOCUP00000010760 | 3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Uncharacterized protein. | 0.504 |
| KDSR | SPTLC1 | ENSOCUP00000012169 | ENSOCUP00000030336 | 3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase long chain base subunit 1. | 0.998 |
| KDSR | SPTLC2 | ENSOCUP00000012169 | ENSOCUP00000040528 | 3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase long chain base subunit 2. | 0.992 |
| KDSR | SPTLC3 | ENSOCUP00000012169 | ENSOCUP00000001125 | 3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase long chain base subunit 3. | 0.992 |
| KDSR | SPTSSA | ENSOCUP00000012169 | ENSOCUP00000019035 | 3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Uncharacterized protein. | 0.421 |
| ORMDL1 | KDSR | ENSOCUP00000010760 | ENSOCUP00000012169 | Uncharacterized protein. | 3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.504 |
| ORMDL1 | SPTLC1 | ENSOCUP00000010760 | ENSOCUP00000030336 | Uncharacterized protein. | Serine palmitoyltransferase long chain base subunit 1. | 0.955 |
| ORMDL1 | SPTLC2 | ENSOCUP00000010760 | ENSOCUP00000040528 | Uncharacterized protein. | Serine palmitoyltransferase long chain base subunit 2. | 0.895 |
| ORMDL1 | SPTLC3 | ENSOCUP00000010760 | ENSOCUP00000001125 | Uncharacterized protein. | Serine palmitoyltransferase long chain base subunit 3. | 0.894 |
| ORMDL1 | SPTSSA | ENSOCUP00000010760 | ENSOCUP00000019035 | Uncharacterized protein. | Uncharacterized protein. | 0.724 |