Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (551 aa)    
Predicted Functional Partners:
SPTSSA
Uncharacterized protein.
    
 0.981
SPTLC1
Serine palmitoyltransferase long chain base subunit 1.
  
0.974
SPTSSB
Serine palmitoyltransferase small subunit B.
    
 0.960
ORMDL3
ORM1-like protein; Negative regulator of sphingolipid synthesis.
    
 0.956
KDSR
3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.955
ORMDL1
Uncharacterized protein.
    
 
 0.873
CERK
Ceramide kinase.
   
 
 0.825
PSPH
Phosphoserine phosphatase.
    
 0.808
CERS2
Ceramide synthase 2.
   
  
 0.802
ORMDL2
ORM1-like protein; Negative regulator of sphingolipid synthesis.
    
 
 0.798
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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