STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THAP1THAP domain containing 1. (213 aa)    
Predicted Functional Partners:
PKIA
cAMP-dependent protein kinase inhibitor alpha; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains; Belongs to the PKI family.
   
   0.769
PRKAR2B
Protein kinase cAMP-dependent type II regulatory subunit beta.
   
 0.708
PRKAR1A
Protein kinase cAMP-dependent type I regulatory subunit alpha.
   
 0.707
CNBD2
Cyclic nucleotide binding domain containing 2.
   
 0.706
PRKAR2A
Protein kinase cAMP-dependent type II regulatory subunit alpha.
   
 0.706
PRKAR1B
Cyclic nucleotide-binding domain-containing protein.
   
 0.706
ENSOCUP00000034602
Cyclic nucleotide-binding domain-containing protein.
   
 0.706
ENSOCUP00000042326
Uncharacterized protein.
   
 0.706
ENSOCUP00000043943
DUF4629 domain-containing protein.
   
 0.706
PLN
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity).
    
  0.691
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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