Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
IGFBP6Insulin like growth factor binding protein 6. (223 aa)    
Predicted Functional Partners:
IGF1
Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]
   
 0.933
IGF2R
Insulin like growth factor 2 receptor.
      
 0.560
IGF1R
Tyrosine-protein kinase receptor.
   
 
 0.533
IGFBP1
Insulin like growth factor binding protein 1.
      
0.523
IGFBP5
Insulin like growth factor binding protein 5.
     
0.488
EFEMP1
EGF containing fibulin extracellular matrix protein 1.
   
 
 0.472
IGFBP4
Insulin like growth factor binding protein 4.
   
 
0.442
CD44
CD44 molecule (Indian blood group).
    
 
 0.432
C3orf49
Chromosome 3 open reading frame 49.
      
 0.427
MFAP5
Microfibril associated protein 5.
   
  
 0.420
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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