| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AHSA1 | CCT7 | ENSOCUP00000001230 | ENSOCUP00000018309 | Activator of HSP90 ATPase activity 1. | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. | 0.745 |
| AHSA1 | CHORDC1 | ENSOCUP00000001230 | ENSOCUP00000012157 | Activator of HSP90 ATPase activity 1. | Uncharacterized protein. | 0.720 |
| AHSA1 | FKBP4 | ENSOCUP00000001230 | ENSOCUP00000048194 | Activator of HSP90 ATPase activity 1. | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May [...] | 0.837 |
| AHSA1 | HSP90AA1 | ENSOCUP00000001230 | ENSOCUP00000036544 | Activator of HSP90 ATPase activity 1. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.760 |
| AHSA1 | HSP90AB1 | ENSOCUP00000001230 | ENSOCUP00000012976 | Activator of HSP90 ATPase activity 1. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.792 |
| AHSA1 | NKTR | ENSOCUP00000001230 | ENSOCUP00000027236 | Activator of HSP90 ATPase activity 1. | Natural killer cell triggering receptor. | 0.713 |
| AHSA1 | PPID | ENSOCUP00000001230 | ENSOCUP00000005706 | Activator of HSP90 ATPase activity 1. | Peptidylprolyl isomerase D. | 0.797 |
| AHSA1 | PPIG | ENSOCUP00000001230 | ENSOCUP00000009538 | Activator of HSP90 ATPase activity 1. | Peptidylprolyl isomerase G. | 0.713 |
| AHSA1 | PTGES3 | ENSOCUP00000001230 | ENSOCUP00000029851 | Activator of HSP90 ATPase activity 1. | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.800 |
| AHSA1 | STIP1 | ENSOCUP00000001230 | ENSOCUP00000029749 | Activator of HSP90 ATPase activity 1. | Stress induced phosphoprotein 1. | 0.919 |
| CCT7 | AHSA1 | ENSOCUP00000018309 | ENSOCUP00000001230 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. | Activator of HSP90 ATPase activity 1. | 0.745 |
| CCT7 | FKBP4 | ENSOCUP00000018309 | ENSOCUP00000048194 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May [...] | 0.480 |
| CCT7 | HSP90AA1 | ENSOCUP00000018309 | ENSOCUP00000036544 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.530 |
| CCT7 | HSP90AB1 | ENSOCUP00000018309 | ENSOCUP00000012976 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.573 |
| CCT7 | PTGES3 | ENSOCUP00000018309 | ENSOCUP00000029851 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.403 |
| CCT7 | STIP1 | ENSOCUP00000018309 | ENSOCUP00000029749 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. | Stress induced phosphoprotein 1. | 0.673 |
| CHORDC1 | AHSA1 | ENSOCUP00000012157 | ENSOCUP00000001230 | Uncharacterized protein. | Activator of HSP90 ATPase activity 1. | 0.720 |
| CHORDC1 | FKBP4 | ENSOCUP00000012157 | ENSOCUP00000048194 | Uncharacterized protein. | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May [...] | 0.404 |
| CHORDC1 | HSP90AA1 | ENSOCUP00000012157 | ENSOCUP00000036544 | Uncharacterized protein. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.734 |
| CHORDC1 | HSP90AB1 | ENSOCUP00000012157 | ENSOCUP00000012976 | Uncharacterized protein. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.651 |
