Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAPPAPappalysin 1. (1498 aa)    
Predicted Functional Partners:
IGFBP5
Insulin like growth factor binding protein 5.
    
 0.893
PRG2
C-type lectin domain-containing protein.
    
 0.888
STC2
Stanniocalcin 2.
    
 
 0.827
PRG3
Proteoglycan 3, pro eosinophil major basic protein 2.
    
 0.751
ANP32A
LRRcap domain-containing protein.
    
   0.725
IGFBP4
Insulin like growth factor binding protein 4.
   
 
 0.722
IGF1
Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]
    
 0.716
ANP32E
Uncharacterized protein.
    
   0.691
G1SWZ6_RABIT
Uncharacterized protein.
    
   0.691
G1T6A9_RABIT
Uncharacterized protein.
    
   0.691
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: medium (80%) [HD]