Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ASIC5Acid sensing ion channel subunit family member 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (502 aa)    
Predicted Functional Partners:
ASIC4
Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
     
0.883
ASIC3
Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
    
0.881
STOML1
PHB domain-containing protein.
    
 0.668
GPR22
G protein-coupled receptor 22.
      
 0.612
GPR142
G protein-coupled receptor 142; Belongs to the G-protein coupled receptor 1 family.
      
 0.605
STOM
Stomatin.
    
 0.578
GPR171
G protein-coupled receptor 171; Belongs to the G-protein coupled receptor 1 family.
      
 0.563
GPR174
G protein-coupled receptor 174.
   
  
 0.562
STOML3
Stomatin like 3.
    
 0.555
SCTR
Secretin receptor; Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodena [...]
   
  
 0.463
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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