RPA1 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRIP	BLM	ENSOCUP00000004508	ENSOCUP00000012010	ATR interacting protein.	BLM RecQ like helicase.	0.613
ATRIP	PCNA	ENSOCUP00000004508	ENSOCUP00000003512	ATR interacting protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.598
ATRIP	RAD51	ENSOCUP00000004508	ENSOCUP00000014527	ATR interacting protein.	DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...]	0.825
ATRIP	RAD52	ENSOCUP00000004508	ENSOCUP00000011685	ATR interacting protein.	RAD52 homolog, DNA repair protein.	0.889
ATRIP	RMI1	ENSOCUP00000004508	ENSOCUP00000020169	ATR interacting protein.	RecQ mediated genome instability 1.	0.726
ATRIP	RPA1	ENSOCUP00000004508	ENSOCUP00000042935	ATR interacting protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.984
ATRIP	RPA2	ENSOCUP00000004508	ENSOCUP00000013917	ATR interacting protein.	Replication protein A2.	0.914
ATRIP	RPA3	ENSOCUP00000004508	ENSOCUP00000000408	ATR interacting protein.	Replication protein A3.	0.860
ATRIP	TOP3A	ENSOCUP00000004508	ENSOCUP00000005547	ATR interacting protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.829
ATRIP	XPA	ENSOCUP00000004508	ENSOCUP00000011935	ATR interacting protein.	XPA, DNA damage recognition and repair factor.	0.512
BLM	ATRIP	ENSOCUP00000012010	ENSOCUP00000004508	BLM RecQ like helicase.	ATR interacting protein.	0.613
BLM	PCNA	ENSOCUP00000012010	ENSOCUP00000003512	BLM RecQ like helicase.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.886
BLM	RAD51	ENSOCUP00000012010	ENSOCUP00000014527	BLM RecQ like helicase.	DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...]	0.991
BLM	RAD52	ENSOCUP00000012010	ENSOCUP00000011685	BLM RecQ like helicase.	RAD52 homolog, DNA repair protein.	0.953
BLM	RMI1	ENSOCUP00000012010	ENSOCUP00000020169	BLM RecQ like helicase.	RecQ mediated genome instability 1.	0.997
BLM	RPA1	ENSOCUP00000012010	ENSOCUP00000042935	BLM RecQ like helicase.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.994
BLM	RPA2	ENSOCUP00000012010	ENSOCUP00000013917	BLM RecQ like helicase.	Replication protein A2.	0.973
BLM	RPA3	ENSOCUP00000012010	ENSOCUP00000000408	BLM RecQ like helicase.	Replication protein A3.	0.987
BLM	TOP3A	ENSOCUP00000012010	ENSOCUP00000005547	BLM RecQ like helicase.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.996
BLM	XPA	ENSOCUP00000012010	ENSOCUP00000011935	BLM RecQ like helicase.	XPA, DNA damage recognition and repair factor.	0.406